Professor and Director, Bioactive Lipids Research Program, Wayne State University
Kenneth Honn, Ph. D., is a distinguished professor and an adjunct professor in the Wayne …

Metabolic competition between tumour cells and immune cells for limited nutrients is an
important feature of the tumour microenvironment (TME) and is closely related to the …

It is widely recognized that malnutrition is the commonest cause of immunodeficiency
worldwide (14). In fact, a recent investigation has determined that food intake increases the …

Inflammatory lipids receive much attention due to their important biological activities.
Knowledge of the chemokine system has also reached a level that makes it interesting in …

Chemotherapy is standard treatments for many malignancies. However, in most cases, this
method is not able to induce apoptosis and in many cases, with cancer recurrence, leads to …

Nutritional intervention with specific fatty acids depresses tumor growth and enhances tumor
responsiveness to chemotherapy. Supplementation of tumors with long chained omega-3 …

Omega-3 (ω-3) fatty acids have been clinically and experimentally associated with the
amelioration of chronic and acute inflammation; however, the mechanisms for these …

Growing evidence indicates that cellular metabolism is a critical determinant of immune cell
viability and function in antitumor immunity and lipid metabolism is important for immune cell …

Objectives. We have previously described that bioactive lysophospholipids—
lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P), and …