Aging is a progressive process that results in the accumulation of intra-and extracellular
alterations that in turn contribute to a reduction in health. Age-related changes in DNA …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Background The well-established association of chronological age with changes in DNA
methylation is primarily founded on the analysis of large sets of blood samples, while …

Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at …

Background Chronological aging-associated changes in the human DNA methylome have
been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites …

Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …

Epigenetic remodeling is one of the major features of the aging process. We recently
demonstrated that DNA methylation of ELOVL2 and FHL2 CpG islands is highly correlated …

The aging phenotype is the result of a complex interaction between genetic, epigenetic and
environmental factors. Evidence suggests that epigenetic changes (ie, a set of reversible …

The normal aging process is a complex phenomenon associated with physiological
alterations in the function of cells and organs over time. Although an attractive candidate for …

Aging is a major risk factor for individuals' health problems. Moreover, environmental signals
have a widespread influence on the aging process. Epigenetic modification, eg DNA …