C Zheng, L Li, R Xu - Cancer Epidemiology, Biomarkers & Prevention, 2019 - AACR
Background: Epigenetic clock, or DNA methylation age, has been shown to highly correlate with chronologic age. Epigenetic age acceleration, the difference between DNA methylation …
The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced chronologic age is one of the most significant risk factors for cancer. Organismal aging is …
Simple Summary The role of DNA methylation in the carcinogenesis of colorectal cancer (CRC) diagnosed< 50 years of age (early-onset CRC or EOCRC) is currently unknown. In …
U Lim, MA Song - Cancer Epigenetics for Precision Medicine: Methods …, 2018 - Springer
Cancer is largely an aging disease. Accelerated biological aging may be the strongest predictor of cancer and other chronic disease risks. In the absence of reliable and …
PA Dugué, JK Bassett, EM Wong, JHE Joo… - JNCI cancer …, 2021 - academic.oup.com
Background We previously investigated the association between 5 “first-generation” measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study …
L Chen, PA Ganz, ME Sehl - Frontiers in Bioinformatics, 2022 - frontiersin.org
Accumulation of somatic mutations and genomic instability are hallmarks of both aging and cancer. Epigenetic alterations occur across cell types and tissues with advancing age. DNA …
S Ambatipudi, S Horvath, F Perrier, C Cuenin… - European journal of …, 2017 - Elsevier
Aim of the study A vast majority of human malignancies are associated with ageing, and age is a strong predictor of cancer risk. Recently, DNA methylation-based marker of ageing …
Background Human aging is associated with profound changes in one of the major epigenetic mechanisms, DNA methylation. Some of these changes occur in a clock-like …
DF Durso, MG Bacalini, C Sala, C Pirazzini… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Changes in blood epigenetic age have been associated with several pathological conditions and have recently been described to anticipate cancer development. In this work …