Focus shifts to antibody cocktails for COVID-19 cytokine storm

C Harrison - Nature biotechnology, 2020 - go.gale.com
On June 5 the Ministry of Health of the Russian Federation registered Biocad's Ilsira
(levilimab) as a treatment for severe COVID-19. Ilsira is one of several monoclonal …

Immunotherapy of COVID-19: inside and beyond IL-6 signalling

G Zizzo, A Tamburello, L Castelnovo, A Laria… - Frontiers in …, 2022 - frontiersin.org
Acting on the cytokine cascade is key to preventing disease progression and death in
hospitalised patients with COVID-19. Among anti-cytokine therapies, interleukin (IL)-6 …

Capturing cytokines with advanced materials: a potential strategy to tackle COVID‐19 cytokine storm

QF Meng, R Tian, H Long, X Wu, J Lai… - Advanced …, 2021 - Wiley Online Library
The COVID‐19 pandemic, induced by severe acute respiratory syndrome coronavirus 2
(SARS‐CoV‐2), has caused great impact on the global economy and people's daily life. In …

New therapeutic approaches for SARS-CoV-2/COVID-19

AJ Rodriguez-Morales, AN Barbosa… - Frontiers in …, 2023 - frontiersin.org
After three years and a half since the pandemic due to the Severe Acute Respiratory
Syndrome coronavirus 2 (SARS-CoV-2) causing Coronavirus Disease 2019 (COVID-19) …

A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans-Signaling and Cellular Infection with SARS-CoV-2

J Ettich, J Werner, HT Weitz, E Mueller… - Journal of …, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can induce mild
to life-threatening symptoms. Especially individuals over 60 years of age or with underlying …

[HTML][HTML] Precision medicine in COVID-19: IL-1β a potential target

V Parisi, D Leosco - Basic to Translational Science, 2020 - jacc.org
As of April 4, 2020, coronavirus disease-2019 (COVID-19) has been confirmed in 1,395,136
people worldwide, with a mortality of approximately 5.8%. Since the COVID-19 outbreak …

Coronavirus immunotherapeutic consortium database

J Mahita, B Ha, A Gambiez, SL Schendel, H Li… - Database, 2023 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has seen multiple anti-SARS-CoV-2 …

Antibody therapies for the treatment of COVID-19

Z Ku, X Ye, GT Salazar, N Zhang, Z An - Antibody Therapeutics, 2020 - academic.oup.com
The outbreak of COVID-19, the disease caused by infection of the coronavirus SARS-CoV-2
that began in December 2019 in Wuhan, China, has caused more than 2 990 559 confirmed …

COVID-19 must catalyse changes to clinical development

R MacKenzie, P Honig, J Sewards… - Nature Reviews Drug …, 2020 - nature.com
The response to the COVID-19 pandemic has shown that exceptional efforts can
dramatically accelerate the clinical development of vaccines. We propose that it is time to …

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Z Ku, X Xie, E Davidson, X Ye, H Su… - Nature …, 2021 - nature.com
Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The
determinants for selecting antibody combinations and the mechanism that antibody cocktails …