Until recently, the blood‐brain barrier was viewed as a static lipid membrane barrier.
Physical attributes of the cerebral endothelial cells such as the presence of tight junctions …

The presence of P‐glycoprotein in the cell plasma membrane limits the penetration of many
cytotoxic substances into cells that express the gene product. There is considerable …

Abstract P-glycoprotein (P-gp) is a highly-conserved membrane protein expressed in
various multidrug-resistant cell lines. P-glycoprotein was detected in capillaries isolated from …

In the central nervous system, the primary targets of the human immunodeficiency virus-1
(HIV-1) are microglia, resulting in a disorder called HIV-1 dementia. P-glycoprotein (P-gp), a …

Recent advances in studies on the blood-brain barrier (BBB) transport of xenobiotics, as well
as nutrients and neuroactive agents, have led to a change in the classical concept that the …

Abstract Analysis of a panel of endothelial cells passaged between 5 and 25 times and
derived from various organs and species demonstrated that murine and porcine cerebral …

P-glycoprotein (P-gp) expression at the blood–brain barrier prevents unwanted blood-borne
toxins and signalling molecules from entering the brain. Primary and immortalised human …

Transport of several xenobiotics including pharmacological agents into or out of the central
nervous system (CNS) involves the expression of ATP-dependent, membrane-bound efflux …

The expression of membrane drug transport systems in the central nervous system plays an
important role in the brain disposition and efficacy of many pharmacological agents used in …

During brain development and blood-brain barrier (BBB) differentiation the expression of P-
glycoprotein (P-gp) may complement the protective function of the placental barrier against …