[HTML][HTML] Domains and functions of spike protein in Sars-Cov-2 in the context of vaccine design

X Xia - Viruses, 2021 - mdpi.com
The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to
gain entry into a cell to initiate infection. Both Pfizer/BioNTech's BNT162b2 and Moderna's …

[HTML][HTML] Mutations and evolution of the SARS-CoV-2 spike protein

N Magazine, T Zhang, Y Wu, MC McGee, G Veggiani… - Viruses, 2022 - mdpi.com
The SARS-CoV-2 spike protein mediates target recognition, cellular entry, and ultimately the
viral infection that leads to various levels of COVID-19 severities. Positive evolutionary …

Molecular biology of the SARs‐CoV‐2 spike protein: A review of current knowledge

C Zhu, G He, Q Yin, L Zeng, X Ye… - Journal of medical …, 2021 - Wiley Online Library
The global coronavirus disease 2019 (COVID‐19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has led to an unprecedented worldwide …

Structure of SARS-CoV-2 spike protein

J Zhang, T Xiao, Y Cai, B Chen - Current opinion in virology, 2021 - Elsevier
The COVID-19 (coronavirus disease 2019) pandemic, caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to loss of human life in millions and …

Structural features of coronavirus SARS-CoV-2 spike protein: Targets for vaccination

A Sternberg, C Naujokat - Life sciences, 2020 - Elsevier
Various human pathogenic viruses employ envelope glycoproteins for host cell receptor
recognition and binding, membrane fusion and viral entry. The spike (S) glycoprotein of …

[HTML][HTML] Flexible, functional, and familiar: characteristics of SARS-CoV-2 spike protein evolution

DS Saputri, S Li, FJ Van Eerden, J Rozewicki… - Frontiers in …, 2020 - frontiersin.org
The SARS-CoV-2 S protein is a major point of interaction between the virus and the human
immune system. As a consequence, the S protein is not a static target but undergoes rapid …

The structural basis of accelerated host cell entry by SARS‐CoV‐2

M Seyran, K Takayama, VN Uversky… - The FEBS …, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of
the pandemic coronavirus disease 2019 (COVID‐19) that exhibits an overwhelming …

Phylogenetic analysis and structural modeling of SARS-CoV-2 spike protein reveals an evolutionary distinct and proteolytically sensitive activation loop

JA Jaimes, NM André, JS Chappie, JK Millet… - Journal of molecular …, 2020 - Elsevier
Abstract The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a
major outbreak of respiratory disease centered on Hubei province, China. It is now a global …

[HTML][HTML] Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2

MM Hatmal, W Alshaer, MAI Al-Hatamleh, M Hatmal… - Cells, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged
in China and caused a disease called coronavirus disease 2019 (COVID-19). The virus …

Structural impact on SARS-CoV-2 spike protein by D614G substitution

J Zhang, Y Cai, T Xiao, J Lu, H Peng, SM Sterling… - Science, 2021 - science.org
Substitution for aspartic acid (D) by glycine (G) at position 614 in the spike (S) protein of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to facilitate rapid …