Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

Cellular senescence is a cell state implicated in various physiological processes and a wide
spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …

Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic
and metabolic changes, and a proinflammatory senescence-associated secretory …

Given the heterogeneity of senescent cells, our knowledge of both the drivers and
consequences of cellular senescence in tissues and organs remains limited, as is our …

Senescence is a state of enduring growth arrest triggered by sublethal cell damage. Given
that senescent cells actively secrete proinflammatory and matrix-remodeling proteins, their …

Senescence is a widely appreciated tumour suppressive mechanism, which acts as a barrier
to cancer development by arresting cell cycle progression in response to harmful stimuli …

Senescent cells that gradually accumulate during aging are one of the leading causes of
aging. While senolytics can improve aging in humans as well as mice by specifically …