How to slow down the ticking clock: age-associated epigenetic alterations and related interventions to extend life span
Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …
overview on recent findings describing the epigenetic changes that arise during aging and …
[HTML][HTML] DeepMAge: a methylation aging clock developed with deep learning
DNA methylation aging clocks have become an invaluable tool in biogerontology research
since their inception in 2013. Today, a variety of machine learning approaches have been …
since their inception in 2013. Today, a variety of machine learning approaches have been …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …
Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes
RF Pérez, P Santamarina, JR Tejedor… - Journal of translational …, 2019 - Springer
Background Early life is a period of drastic epigenetic remodeling in which the epigenome is
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
especially sensitive to extrinsic and intrinsic influence. However, the epigenome-wide …
Back to the future: epigenetic clock plasticity towards healthy aging
K Declerck, WV Berghe - Mechanisms of ageing and development, 2018 - Elsevier
Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …
longevity, yet the causes and functional consequences of these variants remain unclear. To …
Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
Epigenetic age-predictor for mice based on three CpG sites
Y Han, M Eipel, J Franzen, V Sakk… - Elife, 2018 - elifesciences.org
Epigenetic clocks for mice were generated based on deep-sequencing analysis of the
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …
Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk
Background Chronological age is a prominent risk factor for many types of cancers including
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …