Cellular senescence represents a distinct cell fate characterized by replicative arrest in
response to a host of extrinsic and intrinsic stresses. Senescence facilitates programming …

Senescence is linked to a wide range of age-associated diseases and physiological
declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Cells respond to many stressors by senescing, acquiring stable growth arrest, morphologic
and metabolic changes, and a proinflammatory senescence-associated secretory …

Cellular senescence is a hallmark of aging, whose onset is linked to a series of both cell and
non-cell autonomous processes, leading to several consequences for the organism. To …

Cellular senescence was initially described in the early 1960s by Hayflick and Moorehead.
They noted sustained cell-cycle arrest after repeated subculturing of human primary cells …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

SnapShot: Cellular Senescence Pathways Page 1 See online version for legends and
references 816 Cell 170, August 10, 2017 © 2017 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cell.2017.07.049 …