Ageing is a major risk factor for developing many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-
suppressive mechanism. However, due to the associated secretory phenotype senescence …

In recent years, cellular senescence has become the focus of attention in multiple areas of
biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by …

Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …

The increasing life expectancy of the world population has become an economic and global
public health problem. Increased life expectancy tracks with a higher incidence of multiple …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Cellular senescence (CS), a state of permanent growth arrest, is intertwined with
tumorigenesis. Due to the absence of specific markers, characterizing senescence levels …

With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …