Cellular senescence refers to a process induced by various types of stress that causes
irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …

Cellular senescence correlates with changes in the transcriptome. To obtain a complete
view on senescence-associated transcription networks and pathways, we assessed by deep …

Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote
tissue remodelling but can negatively affect regenerative capacities of tissues and contribute …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Cellular senescence is a stress response, which can be evoked in all type of somatic cells
by different stimuli. Senescent cells accumulate in the body and participate in aging and …

Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect
associated with a range of chronic and age‐related diseases. Since the discovery of the first …

Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and
neurodegenerative disorders. Although we are far from understanding the biological basis of …

Cellular senescence in cancer development is known to have tumor‐suppressive and tumor‐
promoting roles. Recent studies have revealed numerous molecular mechanisms of …

Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …

Cellular senescence is a process that results in irreversible cell-cycle arrest, and is thought
to be an autonomous tumor-suppressor mechanism. During senescence, cells develop …