Parkinson's disease (PD) is associated with a loss of neurons from the midbrain. The cause
of PD is unknown, but it is established that certain neurotoxins can cause similar syndromes …

Decreased blood–brain barrier (BBB) efflux function of the P-glycoprotein (P-gp) transport
system could facilitate the accumulation of toxic compounds in the brain, increasing the risk …

In vivo studies have shown that blood–brain barrier (BBB) dysfunction is involved in the
course of Parkinson's disease (PD). However, these have lacked either anatomic definition …

We have evaluated the possibility that changes in the vascular system may constitute a
contributing factor for the death of nigral dopaminergic neurons in Parkinson's disease …

Background Blood–brain barrier (BBB) disruption has been noted in animal models of
Parkinson's disease (PD) and forms the basis of the vascular hypothesis of …

[Frontiers in Bioscience 19, 272-280, January 1, 2014] 272 Disruption of the blood-brain barrier
in parkinson’s disease: curse Page 1 [Frontiers in Bioscience 19, 272-280, January 1, 2014] 272 …

Regional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO,) were determined in
six normals, six unilateral Parkinson's disease (PD) patients, and eight bilateral PD patients …

Deep brain stimulation of the subthalamic nucleus (STN DBS) improves motor symptoms in
idiopathic Parkinson's disease, yet the mechanism of action remains unclear. Previous …

The blood‐brain barrier (BBB) is important physiologically. Pathologically, BBB disruption
has been implicated in a wide spectrum of neurological disorders including Parkinson's …

Protection of the brain is strengthened by active transport and ABC transporters. P-
glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by …