Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing
Background DNA methylation changes with age. Chronological age predictors built from
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
DNA methylation are termed 'epigenetic clocks'. The deviation of predicted age from the …
A pan-tissue DNA-methylation epigenetic clock based on deep learning
Several age predictors based on DNA methylation, dubbed epigenetic clocks, have been
created in recent years, with the vast majority based on regularized linear regression. This …
created in recent years, with the vast majority based on regularized linear regression. This …
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex
GL Shireby, JP Davies, PT Francis, J Burrage… - Brain, 2020 - academic.oup.com
Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …
as 'epigenetic clocks', which have been widely used to identify differences between …
Multi-tissue DNA methylation age predictor in mouse
Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …
predictive of chronological and biological age. However, it is not known whether these …
[HTML][HTML] Chronological age prediction: developmental evaluation of DNA methylation-based machine learning models
Epigenetic clock, a highly accurate age estimator based on DNA methylation (DNAm) level,
is the basis for predicting mortality/morbidity and elucidating the molecular mechanism of …
is the basis for predicting mortality/morbidity and elucidating the molecular mechanism of …
methylclock: a Bioconductor package to estimate DNA methylation age
D Pelegí-Sisó, P De Prado, J Ronkainen… - …, 2021 - academic.oup.com
Motivation Ageing is a biological and psychosocial process related to diseases and
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …
mortality. It correlates with changes in DNA methylation (DNAm) in all human tissues …
Systematic underestimation of the epigenetic clock and age acceleration in older subjects
Abstract Background The Horvath epigenetic clock is widely used. It predicts age quite well
from 353 CpG sites in the DNA methylation profile in unknown samples and has been used …
from 353 CpG sites in the DNA methylation profile in unknown samples and has been used …
Tracking the epigenetic clock across the human life course: a meta-analysis of longitudinal cohort data
Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …
DNA methylation age of human tissues and cell types
S Horvath - Genome biology, 2013 - Springer
Background It is not yet known whether DNA methylation levels can be used to accurately
predict age across a broad spectrum of human tissues and cell types, nor whether the …
predict age across a broad spectrum of human tissues and cell types, nor whether the …
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging
Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …
models using DNA methylation data can create “epigenetic clocks” which are proposed to …