Background Human aging is associated with DNA methylation changes at specific sites in
the genome. These epigenetic modifications may be used to track donor age for forensic …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …

The incidence of cancer, adjusted for secular trends, is directly related to age, and advanced
chronologic age is one of the most significant risk factors for cancer. Organismal aging is …

Background DNA methylation changes over life at specific sites in the genome, which can
be used to estimate “biological age.” The aim of this population‐based longitudinal cohort …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional
longevity. Materials & methods: Participants were from three adult cohorts with blood DNA …

Epigenetic clocks for mice were generated based on deep-sequencing analysis of the
methylome. Here, we demonstrate that site-specific analysis of DNA methylation levels by …

DNA methylation dynamics have emerged as a promising biomarker of mammalian aging,
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Aging clocks dissociate biological from chronological age. The estimation of biological age
is important for identifying gerontogenes and assessing environmental, nutritional, or …