Background Ageing is associated with DNA methylation changes in all human tissues, and
epigenetic markers can estimate chronological age based on DNA methylation patterns …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

Background The trajectory of frailty in older adults is important to public health; therefore,
markers that may help predict this and other important outcomes could be beneficial …

Aging is associated with highly reproducible DNA methylation (DNAm) changes, which may
contribute to higher prevalence of malignant diseases in the elderly. In this study, we …

Transcriptomic data is often affected by uncontrolled variation among samples that can
obscure and confound the effects of interest. This variation is frequently due to unintended …

I recently described an epigenetic biomarker of aging based on DNA methylation (DNAm)
levels [1]. Unfortunately, I made a software coding error in my analysis of the cancer data …

Identifying genes regulating the pace of epigenetic ageing represents a new frontier in
genome-wide association studies (GWASs). Here using 1,796 brain samples from 1,163 …

Background: Measures to quantify changes in the pace of biological aging in response to
intervention are needed to evaluate geroprotective interventions for humans. Previously, we …

Young blood plasma is known to confer beneficial effects on various organs in mice.
However, it was not known whether young plasma rejuvenates cells and tissues at the …