Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
presence of extracellular amyloid plaques consisting of Amyloid-β peptide (Aβ) aggregates …

Aggregates of Aβ peptide and the microtubule-associated protein tau are key molecular
hallmarks of Alzheimer's disease (AD). However, the interaction between these two …

A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease
(AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of …

Transgenic mouse models that independently express mutations in amyloid precursor
protein (APP) and tau have proven useful for the study of the neurological consequences of …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss
and personality changes, eventually leading to dementia. The pathological hallmarks of AD …

Protein misfolding and aggregation are hallmarks of neurodegenerative diseases such as
Alzheimer's disease (AD). In AD, the accumulation and aggregation of tau and the amyloid …

Alzheimer's disease (AD) is characterised by neurofibrillary tangles composed of hyper-
phosphorylated tau, and neuritic plaques composed of misfolded amyloid peptide (Aβ42). It …

This review describes several transgenic mouse models of Alzheimer's disease (AD), a
devastating neurodegenerative disorder that causes progressive cognitive decline and is …

Even though the idea that amyloid β peptide accumulation is the primary event in the
pathogenesis of Alzheimer's disease has become the leading hypothesis, the causal link …

Alzheimer's disease (AD) is characterized by three primary pathologies in the brain: amyloid
plaques, neurofibrillary tangles, and neuron loss. Mouse models have been useful for …