Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, B Flynn, KE Foulds… - … England Journal of …, 2020 - Mass Medical Soc
Background Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed.
The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on …

[HTML][HTML] Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung

M Gagne, KS Corbett, BJ Flynn, KE Foulds, DA Wagner… - Cell, 2022 - cell.com
Summary mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time;
however, there are limited data on the impact of durability of immune responses on …

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

KS Corbett, M Gagne, DA Wagner, S O'Connell… - Science, 2021 - science.org
Neutralizing antibody responses gradually wane against several variants of concern (VOCs)
after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

KS Corbett, AP Werner, SO Connell, M Gagne… - Nature …, 2021 - nature.com
Abstract B. 1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variant most resistant to antibody neutralization. We demonstrate how the dose and number …

Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - Science, 2021 - science.org
INTRODUCTION Mass vaccination against severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) offers the most efficient public health intervention to control the COVID-19 …

Immune correlates of protection by mRNA-1273 immunization against SARS-CoV-2 infection in nonhuman primates

KS Corbett, MC Nason, B Flach, M Gagne, S O'Connell… - BioRxiv, 2021 - biorxiv.org
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy.
The nonhuman primate (NHP) model of SARS-CoV-2 infection replicates key features of …

An mRNA vaccine against SARS-CoV-2—preliminary report

LA Jackson, EJ Anderson, NG Rouphael… - New England journal …, 2020 - Mass Medical Soc
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged
in late 2019 and spread globally, prompting an international effort to accelerate …

[HTML][HTML] A preliminary report of a randomized controlled phase 2 trial of the safety and immunogenicity of mRNA-1273 SARS-CoV-2 vaccine

L Chu, R McPhee, W Huang, H Bennett, R Pajon… - Vaccine, 2021 - Elsevier
Background Vaccines are urgently needed to prevent the global spread of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed the safety and …

Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine

LR Baden, HM El Sahly, B Essink… - New England journal …, 2021 - Mass Medical Soc
Background Vaccines are needed to prevent coronavirus disease 2019 (Covid-19) and to
protect persons who are at high risk for complications. The mRNA-1273 vaccine is a lipid …

Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

MF Tioni, R Jordan, AS Pena, A Garg, D Wu, SI Phan… - npj Vaccines, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA virus that relies on its …