The emergence of viral respiratory pathogens with pandemic potential, such as severe acute
respiratory syndrome coronavirus (SARS-CoV) and influenza A H5N1, urges the need for …

Age is a risk factor for coronavirus disease 2019 (COVID-19)-associated morbidity and
mortality in humans; hence, in this study, we compared the course of severe acute …

Non-human primate models will expedite therapeutics and vaccines for coronavirus disease
2019 (COVID-19) to clinical trials. Here, we compare acute severe acute respiratory …

Highly pathogenic human respiratory coronaviruses cause acute lethal disease
characterized by exuberant inflammatory responses and lung damage. However, the factors …

Morbidity and mortality in response to SARS-CoV-2 infection are significantly elevated in
people of advanced age. To understand the underlying biology of this phenotype, we utilize …

Older individuals are at higher risk of SARS-CoV-2 infection and severe outcomes, but the
underlying mechanisms are incompletely understood. In addition, how age modulates SARS …

Dysregulated type I interferon (IFN-I) expression can lead to severe pathology and disease.
In this issue of Cell Host & Microbe, Channappanavar et al.(2016) use a SARS-coronavirus …

The diversity of COVID-19 disease in otherwise healthy people, from seemingly
asymptomatic infection to severe life-threatening disease, is not clearly understood. We …

Type I interferons (IFN-I) are critical mediators of innate control of viral infections but also
drive the recruitment of inflammatory cells to sites of infection, a key feature of severe …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a wide range of
disease severity, ranging from asymptomatic infection to a life-threating illness, particularly …