A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects
The central importance of epigenetics to the aging process is increasingly being recognized.
Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA …
Here we perform a methylome-wide association study (MWAS) of aging in whole blood DNA …
Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
L Kananen, S Marttila, T Nevalainen, J Jylhävä… - BMC genomics, 2016 - Springer
Background Chronological aging-associated changes in the human DNA methylome have
been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites …
been studied by multiple epigenome-wide association studies (EWASs). Certain CpG sites …
Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites
I Florath, K Butterbach, H Müller… - Human molecular …, 2014 - academic.oup.com
Understanding the role of epigenetic modifications, eg DNA methylation, in the process of
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
aging requires the characterization of methylation patterns in large cohorts. We analysed> …
Genotype effects contribute to variation in longitudinal methylome patterns in older people
Background DNA methylation levels change along with age, but few studies have examined
the variation in the rate of such changes between individuals. Methods We performed a …
the variation in the rate of such changes between individuals. Methods We performed a …
Distinct DNA methylomes of newborns and centenarians
Human aging cannot be fully understood in terms of the constrained genetic setting.
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Epigenetic drift is an alternative means of explaining age-associated alterations. To address …
Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
S Marttila, L Kananen, S Häyrynen, J Jylhävä… - BMC genomics, 2015 - Springer
Background Changes in DNA methylation are among the mechanisms contributing to the
ageing process. We sought to identify ageing-associated DNA methylation changes at …
ageing process. We sought to identify ageing-associated DNA methylation changes at …
New targeted approaches for epigenetic age predictions
Background Age-associated DNA methylation changes provide a promising biomarker for
the aging process. While genome-wide DNA methylation profiles enable robust age …
the aging process. While genome-wide DNA methylation profiles enable robust age …
[HTML][HTML] Local CpG density affects the trajectory and variance of age-associated DNA methylation changes
Background DNA methylation is an epigenetic mark associated with the repression of gene
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
promoters. Its pattern in the genome is disrupted with age and these changes can be used to …
[PDF][PDF] Genome-wide methylation profiles reveal quantitative views of human aging rates
The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …
many fields, including disease prevention and treatment, forensics, and extension of life …
Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape
K Day, LL Waite, A Thalacker-Mercer, A West… - Genome biology, 2013 - Springer
Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …
tissues, although the mechanisms and specificity of this process are still poorly understood …