Imaging blood–brain barrier dysfunction in animal disease models

A Wunder, K Schoknecht, DB Stanimirovic, O Prager… - …, 2012 - Wiley Online Library
The blood–brain barrier (BBB) is a highly complex structure, which separates the
extracellular fluid of the central nervous system (CNS) from the blood of CNS vessels. A …

In vivo methods for imaging blood–brain barrier function and dysfunction

WJ Harris, MC Asselin, R Hinz, LM Parkes… - European journal of …, 2023 - Springer
The blood–brain barrier (BBB) is the interface between the central nervous system and
systemic circulation. It tightly regulates what enters and is removed from the brain …

Functional morphology of the blood–brain barrier in health and disease

S Liebner, RM Dijkhuizen, Y Reiss, KH Plate… - Acta …, 2018 - Springer
The adult quiescent blood–brain barrier (BBB), a structure organised by endothelial cells
through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular …

Analyzing the blood–brain barrier: The benefits of medical imaging in research and clinical practice

Y Chassidim, U Vazana, O Prager, R Veksler… - Seminars in Cell & …, 2015 - Elsevier
A dysfunctional BBB is a common feature in a variety of brain disorders, a fact stressing the
need for diagnostic tools designed to assess brain vessels' permeability in space and time …

Imaging blood-brain barrier dysfunction: A state-of-the-art review from a clinical perspective

P Moyaert, BE Padrela, CA Morgan, J Petr… - Frontiers in aging …, 2023 - frontiersin.org
The blood-brain barrier (BBB) consists of specialized cells that tightly regulate the in-and
outflow of molecules from the blood to brain parenchyma, protecting the brain's …

An in vivo blood-brain barrier permeability assay in mice using fluorescently labeled tracers

K Devraj, S Guérit, J Macas, Y Reiss - JoVE (Journal of Visualized …, 2018 - jove.com
Blood-brain barrier (BBB) is a specialized barrier that protects the brain microenvironment
from toxins and pathogens in the circulation and maintains brain homeostasis. The principal …

Blood–brain barrier imaging in human neuropathologies

R Veksler, I Shelef, A Friedman - Archives of medical research, 2014 - Elsevier
The blood–brain barrier (BBB) is essential for normal function of the brain, and its role in
many brain pathologies has been the focus of numerous studies during the last decades …

Pathophysiology of the blood–brain barrier: animal models and methods

BT Hawkins, RD Egleton - Current topics in developmental biology, 2007 - Elsevier
The specialized cerebral microvascular endothelium interacts with the cellular milieu of the
brain and extracellular matrix to form a neurovascular unit, one aspect of which is a …

Longitudinal assessment of blood–brain barrier leakage during epileptogenesis in rats. A quantitative MRI study

EA Van Vliet, WM Otte, JA Gorter, RM Dijkhuizen… - Neurobiology of …, 2014 - Elsevier
The blood–brain barrier (BBB) plays an important role in the homeostasis of the brain. BBB
dysfunction has been implicated in the pathophysiology of various neurological disorders …

Translational stroke research on blood-brain barrier damage: challenges, perspectives, and goals

Y Shi, RK Leak, RF Keep, J Chen - Translational Stroke Research, 2016 - Springer
Over the past few decades, basic and clinical research has identified numerous risk factors
for the development of stroke and led to major improvements in health management in the …