Study question Are the single nucleotide polymorphisms (SNPs) rs2075230, rs6259 and
rs727428 at the sex hormone-binding globulin (SHBG) locus, which were identified by …

Context: Testosterone (T) is a central androgenic hormone, and sex hormone-binding
globulin (SHBG) is the major determinant of its bioactivity. There are no acknowledged …

Background Sex hormones and gonadotropins exert a wide variety of effects in
physiological and pathological processes. Accumulated evidence shows a strong heritable …

Testosterone concentrations in men are associated with cardiovascular morbidity,
osteoporosis, and mortality and are affected by age, smoking, and obesity. Because of …

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and
biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has …

We conducted a community-based cross-sectional study to evaluate the role of genetics in
determining the individual difference in total testosterone and sex hormone-binding globulin …

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and
biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has …

Twin studies suggest a heritable component to circulating sex steroid hormones and sex
hormone-binding globulin (SHBG). In the NCI-Breast and Prostate Cancer Cohort …

Low testosterone levels are associated with metabolic and cardiovascular disease risk
factor, and have been shown to predict type 2 diabetes mellitus (T2 DM), myocardial …

Context Genetic variation in sex hormone-binding globulin (SHBG) structure may affect
estimates of sex steroid exposure by altering the affinity of the protein for its ligand …