Targeting the “cytokine storm” for therapeutic benefit

RV D'Elia, K Harrison, PC Oyston… - Clinical and Vaccine …, 2013 - Am Soc Microbiol
Inflammation is the body's first line of defense against infection or injury, responding to
challenges by activating innate and adaptive responses. Microbes have evolved a diverse …

[HTML][HTML] Pathogenesis and treatment of cytokine storm induced by infectious diseases

XD Tang, TT Ji, JR Dong, H Feng, FQ Chen… - International journal of …, 2021 - mdpi.com
Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that
most often occur after an overreactive immune system is activated by an acute systemic …

Into the eye of the cytokine storm

JR Tisoncik, MJ Korth, CP Simmons… - Microbiology and …, 2012 - Am Soc Microbiol
The cytokine storm has captured the attention of the public and the scientific community
alike, and while the general notion of an excessive or uncontrolled release of …

[HTML][HTML] Cytokine storms in infectious diseases

JR Teijaro - Seminars in immunopathology, 2017 - Springer
The term Bcytokine storm^ has been adopted in the past several decades as a phrase to
describe the aberrant production of soluble mediators and the accompanying …

[HTML][HTML] The roles of neutrophils in cytokine storms

L Chan, N Karimi, S Morovati, K Alizadeh, JE Kakish… - Viruses, 2021 - mdpi.com
A cytokine storm is an abnormal discharge of soluble mediators following an inappropriate
inflammatory response that leads to immunopathological events. Cytokine storms can occur …

Averting inflammation by targeting the cytokine environment

M Kopf, MF Bachmann, BJ Marsland - Nature Reviews Drug Discovery, 2010 - nature.com
Cytokines are key instigators and regulators of immune responses and therefore hold great
potential as targets for new therapeutic strategies. However, the selection of which cytokines …

Constitutive inflammatory cytokine storm: a major threat to human health

KK Gupta, MA Khan, SK Singh - Journal of Interferon & Cytokine …, 2020 - liebertpub.com
Immune cells secrete small protein molecules that aim for cell–cell communications. These
small molecules are called cytokines. Targeting cancer cells with administration of bispecific …

[HTML][HTML] Cytokine storm—definition, causes, and implications

D Jarczak, A Nierhaus - International journal of molecular sciences, 2022 - mdpi.com
The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

[HTML][HTML] The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Biologics for targeting inflammatory cytokines, clinical uses, and limitations

P Rider, Y Carmi, I Cohen - International journal of cell biology, 2016 - Wiley Online Library
Proinflammatory cytokines are potent mediators of numerous biological processes and are
tightly regulated in the body. Chronic uncontrolled levels of such cytokines can initiate and …