ABSTRACT DNA methylation at cytosine-phosphate-guanine (CpG) dinucleotides changes
as a function of age in humans and animal models, a process that may contribute to chronic …

Methylation of DNA is intimately involved in control of mammalian/vertebrate gene
expression as part of a complex epigenetic regulatory system. We hypothesize that DNA …

Aging is a progressive process that results in the accumulation of intra-and extracellular
alterations that in turn contribute to a reduction in health. Age-related changes in DNA …

Age-related changes in DNA methylation have been implicated in cellular senescence and
longevity, yet the causes and functional consequences of these variants remain unclear. To …

Ageing is often characterised by progressive accumulation of damage, and it is one of the
most important risk factors for chronic disease development. Epigenetic mechanisms …

Abstract Changes in DNA methylation with age are observed across the tree of life. The
stereotypical nature of these changes can be modeled to produce epigenetic clocks capable …

Ageing is one of the major risk factors for many chronic diseases. One key point that needs
to be addressed to address ageing-related issues is to precisely quantify individual ageing …

Aging is associated with dramatic changes to DNA methylation (DNAm), although the
causes and consequences of such alterations are unknown. Our ability to experimentally …

DNA methylation age (DNAm age, epigenetic clock) is a novel and promising biomarker of
aging. It is calculated from the methylation fraction of specific cytosine phosphate guanine …

Epigenetic mechanisms such as DNA methylation have been implicated in a number of
diseases including cancer, heart disease, autoimmune disorders, and neurodegenerative …