Biological aging measures based on blood DNA methylation and risk of cancer: a prospective study

PA Dugué, JK Bassett, EM Wong, JHE Joo… - JNCI cancer …, 2021 - academic.oup.com
Background We previously investigated the association between 5 “first-generation”
measures of epigenetic aging and cancer risk in the Melbourne Collaborative Cohort Study …

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

PA Dugué, JK Bassett, JHE Joo… - … journal of cancer, 2018 - Wiley Online Library
The association between aging and cancer is complex. Recent studies have developed
measures of biological aging based on DNA methylation and called them “age …

DNA methylation age as a biomarker for cancer

CHE Lau, O Robinson - International Journal of Cancer, 2021 - Wiley Online Library
Cancer is well established as an age‐associated disease, and there is substantial overlap in
the molecular, cellular and physiological changes observed with both ageing and the …

DNA methylation as a biomarker of aging in epidemiologic studies

U Lim, MA Song - Cancer Epigenetics for Precision Medicine: Methods …, 2018 - Springer
Cancer is largely an aging disease. Accelerated biological aging may be the strongest
predictor of cancer and other chronic disease risks. In the absence of reliable and …

Associations of DNA methylation algorithms of aging and cancer risk: Results from a prospective cohort study

X Li, B Schöttker, B Holleczek, H Brenner - EBioMedicine, 2022 - thelancet.com
Background Previous studies have shown that three DNA methylation (DNAm) based
algorithms of aging, DNAm PhenoAge acceleration (AgeAccelPheno), DNAm GrimAge …

[HTML][HTML] DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative

ME Levine, HD Hosgood, B Chen, D Absher… - Aging (Albany …, 2015 - ncbi.nlm.nih.gov
Lung cancer is considered an age-associated disease, whose progression is in part due to
accumulation of genomic instability as well as age-related decline in system integrity and …

Association of DNA methylation-based biological age with health risk factors and overall and cause-specific mortality

PA Dugué, JK Bassett, JHE Joo… - American journal of …, 2018 - academic.oup.com
Measures of biological age based on blood DNA methylation, referred to as age
acceleration (AA), have been developed. We examined whether AA was associated with …

Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort

L Perna, Y Zhang, U Mons, B Holleczek, KU Saum… - Clinical …, 2016 - Springer
Background Previous studies have developed models predicting methylation age from DNA
methylation in blood and other tissues (epigenetic clock) and suggested the difference …

Dysfunctional epigenetic aging of the normal colon and colorectal cancer risk

T Wang, SK Maden, GE Luebeck, CI Li… - Clinical …, 2020 - Springer
Background Chronological age is a prominent risk factor for many types of cancers including
colorectal cancer (CRC). Yet, the risk of CRC varies substantially between individuals, even …

[HTML][HTML] Acceleration of leukocytes' epigenetic age as an early tumor and sex-specific marker of breast and colorectal cancer

DF Durso, MG Bacalini, C Sala, C Pirazzini… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Changes in blood epigenetic age have been associated with several pathological
conditions and have recently been described to anticipate cancer development. In this work …