Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern: the fragile balance between infections and autoimmunity

A Picchianti Diamanti, MM Rosado, C Pioli… - International journal of …, 2020 - mdpi.com
On 7 January 2020, researchers isolated and sequenced in China from patients with severe
pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide …

Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality

Y Que, C Hu, K Wan, P Hu, R Wang, J Luo… - International reviews …, 2022 - Taylor & Francis
Abstract The coronavirus disease 2019 (COVID-19) triggered by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) erupted in Hubei Province of China in December …

The deregulated immune reaction and cytokines release storm (CRS) in COVID-19 disease

R Pasrija, M Naime - International Immunopharmacology, 2021 - Elsevier
COVID-19 caused by the SARS-CoV-2 virus, accompanies an unprecedented spike in
cytokines levels termed cytokines release syndrome (CRS), in critically ill patients. Clinicians …

Definition and risks of cytokine release syndrome in 11 critically ill COVID-19 patients with pneumonia: analysis of disease characteristics

W Wang, X Liu, S Wu, S Chen, Y Li… - The Journal of …, 2020 - academic.oup.com
Abstract Corona virus disease 2019 (COVID-19) patients with severe immune abnormalities
are at risk of cytokine release syndrome (CRS). The definition, prevention, and treatment of …

Cytokine release syndrome in severe COVID-19

JB Moore, CH June - Science, 2020 - science.org
In December 2019, a new strain of coronavirus, severe acute respiratory syndrome–
coronavirus 2 (SARS-CoV-2), was recognized to have emerged in Wuhan, China. Along …

SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

M Olbei, I Hautefort, D Modos, A Treveil… - Frontiers in …, 2021 - frontiersin.org
Hyper-induction of pro-inflammatory cytokines, also known as a cytokine storm or cytokine
release syndrome (CRS), is one of the key aspects of the currently ongoing SARS-CoV-2 …

Cytokine release syndrome (CRS) and nicotine in COVID-19 patients: trying to calm the storm

J Gonzalez-Rubio, C Navarro-Lopez… - Frontiers in …, 2020 - frontiersin.org
SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It causes severe
acute respiratory syndrome (COVID-19), which is fatal in many cases, and is characterized …

Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)?

B Liu, M Li, Z Zhou, X Guan, Y Xiang - Journal of autoimmunity, 2020 - Elsevier
The emergent outbreak of coronavirus disease 2019 (COVID-19) has caused a global
pandemic. Acute respiratory distress syndrome (ARDS) and multiorgan dysfunction are …

Harnessing the immune system to overcome cytokine storm and reduce viral load in COVID-19: a review of the phases of illness and therapeutic agents

S Khadke, N Ahmed, N Ahmed, R Ratts, S Raju… - Virology journal, 2020 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is caused by Severe Acute
Respiratory Syndrome Coronavirus 2 (SARS-CoV-2, previously named 2019-nCov), a novel …

Immune alterations in a patient with SARS-CoV-2-related acute respiratory distress syndrome

L Bouadma, A Wiedemann, J Patrier… - Journal of clinical …, 2020 - Springer
We report a longitudinal analysis of the immune response associated with a fatal case of
COVID-19 in Europe. This patient exhibited a rapid evolution towards multiorgan failure …