SARS-CoV-2 triggers inflammatory responses and cell death through caspase-8 activation

S Li, Y Zhang, Z Guan, H Li, M Ye, X Chen… - Signal transduction and …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to
respiratory illness and multi-organ failure in critically ill patients. Although the virus-induced …

[HTML][HTML] SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

C Junqueira, Â Crespo, S Ranjbar… - Research …, 2021 - ncbi.nlm.nih.gov
SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and
death in a minority of patients. Although severe COVID-19 disease is linked to exuberant …

Programmed cell death: the pathways to severe COVID-19?

SM Bader, JP Cooney, M Pellegrini… - Biochemical …, 2022 - portlandpress.com
Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease
pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts …

Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis

L Zhu, X Li, F Xu, Z Yin, J Jin, Z Liu, H Qi… - Chaos, Solitons & …, 2022 - Elsevier
The newly identified cell death type, pyroptosis plays crucial roles in various diseases. Most
recently, mounting evidence accumulates that pyroptotic signaling is highly correlated with …

SARS‐CoV‐2 nucleocapsid suppresses host pyroptosis by blocking Gasdermin D cleavage

J Ma, F Zhu, M Zhao, F Shao, D Yu, J Ma… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is an emerging coronavirus that causes dysfunctions in multiple human cells
and tissues. Studies have looked at the entry of SARS‐CoV‐2 into host cells mediated by …

Apoptosis induced by SARS-CoV-2: can we target it?

A Donia, H Bokhari - Apoptosis, 2021 - Springer
Some viruses are known to be associated with increased apoptosis. Apoptotic cell death
triggered by these viruses has a complex role in host antiviral immunity, and might facilitate …

[HTML][HTML] COVID-19 patients with high TNF/IFN-γ levels show hallmarks of PANoptosis, an inflammatory cell death

Y Palacios, LA Ramón-Luing, A Ruiz… - Microbes and …, 2023 - Elsevier
TNF and IFN-γ trigger cell damage during SARS CoV-2 infection; these cytokines can
induce senescence and a cell death process called PANoptosis. This study included 138 …

[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

Emerging molecular prospective of SARS-CoV-2: Feasible nanotechnology based detection and inhibition

S Patra, RG Kerry, GK Maurya, B Panigrahi… - Frontiers in …, 2020 - frontiersin.org
The rapid dissemination of SARS-CoV-2 demonstrates how vulnerable it can make
communities and is why it has attained the status of global pandemic. According to the …

The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications

NV Ivanisenko, K Seyrek, NA Kolchanov… - Cell death …, 2020 - nature.com
The current pandemic of novel severe acute respiratory syndrome coronavirus (SARS-CoV-
2) poses a significant global public health threat. While urgent regulatory measures in …