Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving …
BACKGROUND: Genetic and environmental factors shape life-long vulnerability to
depression, but most gene–environment interaction (G× E) research has focused on cross …
depression, but most gene–environment interaction (G× E) research has focused on cross …
Interaction between specific forms of childhood maltreatment and the serotonin transporter gene (5-HTT) in recurrent depressive disorder
BACKGROUND: There is inconsistent evidence of interaction between stressful events and
a serotonin transporter promoter polymorphism (5-HTTLPR) in depression. Recent studies …
a serotonin transporter promoter polymorphism (5-HTTLPR) in depression. Recent studies …
Serotonin transporter length polymorphism, childhood maltreatment, and chronic depression: a specific gene–environment interaction
GW Brown, M Ban, TKJ Craig, TO Harris… - Depression and …, 2013 - Wiley Online Library
Background Key questions about the interaction between the serotonin transporter length
polymorphism (5‐HTTLPR) and stress in the etiology of depression remain unresolved. We …
polymorphism (5‐HTTLPR) and stress in the etiology of depression remain unresolved. We …
Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene–environment interaction
GW Brown, TO Harris - Journal of affective disorders, 2008 - Elsevier
Studies of the interaction of the serotonin transporter genotype and environment upon adult
depression (G× E) have suggested a role for both childhood maltreatment and stressful life …
depression (G× E) have suggested a role for both childhood maltreatment and stressful life …
Social supports and serotonin transporter gene moderate depression in maltreated children
In this study, measures of the quality and availability of social supports were found to
moderate risk for depression associated with a history of maltreatment and the presence of …
moderate risk for depression associated with a history of maltreatment and the presence of …
[HTML][HTML] Depression, stressful life events, and the impact of variation in the serotonin transporter: Findings from the National Longitudinal Study of Adolescent to Adult …
BC Haberstick, JD Boardman, B Wagner, A Smolen… - PLoS …, 2016 - journals.plos.org
Background The low transcriptionally efficient short-allele of the 5HTTLPR serotonin
transporter polymorphism has been implicated to moderate the relationship between the …
transporter polymorphism has been implicated to moderate the relationship between the …
Association of Adverse Childhood Environment and 5-HTTLPR Genotype With Late-Life Depression
K Ritchie, I Jaussent, R Stewart, AM Dupuy… - The Journal of clinical …, 2009 - psychiatrist.com
Objective: Neurobiological and clinical studies suggest that childhood maltreatment may
result in functional and structural nervous system changes that predispose the individual to …
result in functional and structural nervous system changes that predispose the individual to …
Serotonin transporter‐linked polymorphic region (5‐HTTLPR) genotype and stressful life events interact to predict preschool‐onset depression: A replication and …
Background Scientific enthusiasm about gene× environment interactions, spurred by the 5‐
HTTLPR (serotonin transporter‐linked polymorphic region)× SLE s (stressful life events) …
HTTLPR (serotonin transporter‐linked polymorphic region)× SLE s (stressful life events) …
Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder
Background: Physical or psychological adversity in childhood is associated with a higher
risk for depression in adulthood, and with persistent serotonergic abnormalities in humans …
risk for depression in adulthood, and with persistent serotonergic abnormalities in humans …
Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology
BACKGROUND: Mixed evidence has suggested that homozygous carriers of the short allele
(s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may be at …
(s/s) of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) may be at …