The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update

R Uher, P McGuffin - Molecular psychiatry, 2010 - nature.com
An updated review of 34 human observational studies indicates that the length
polymorphism of the serotonin transporter gene moderates the effect of environmental …

Moderation of adult depression by the serotonin transporter promoter variant (5‐HTTLPR), childhood abuse and adult traumatic events in a general population sample

HJ Grabe, C Schwahn, J Mahler… - American Journal of …, 2012 - Wiley Online Library
The impact of the promoter polymorphisms of the serotonin transporter (5‐HTTLPR) on
mood has been studied by two‐way interaction models comprising one environmental factor …

The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study

B Gutiérrez, JÁ Bellón, M Rivera, E Molina… - Journal of Psychiatry and …, 2015 - jpn.ca
Background: There is limited evidence for a moderating role of both serotonin transporter
(SERT) and brain-derived neurotrophic factor (BDNF) genes on the risk for major depression …

[HTML][HTML] Serotonin transporter genotype 5HTTLPR as a marker of differential susceptibility? A meta-analysis of child and adolescent gene-by-environment studies

MH Van IJzendoorn, J Belsky… - Translational …, 2012 - nature.com
We present results of a meta-analysis of gene-by-environment (G× E) studies involving the
serotonin transporter genotype 5HTTLPR to evaluate empirical support for two competing …

Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients

BE Gibb, JE McGeary, CG Beevers… - Suicide and life …, 2006 - Guilford Press
There is growing evidence that a functional polymorphism in the serotonin transporter gene
(5-HTTLPR) moderates the impact of negative life events (eg, childhood abuse) on the …

Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis

CS Carver, SL Johnson, J Joormann, J LeMoult… - Journal of affective …, 2011 - Elsevier
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic
factor (BDNF) val66met polymorphism have both been linked to depression symptoms and …

Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder

PG Surtees, NWJ Wainwright, SAG Willis-Owen… - Biological …, 2006 - Elsevier
BACKGROUND: Recent evidence has suggested that the short allele of the serotonin
transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR of the human serotonin …

Brain-derived neurotrophic factor–5-HTTLPR gene interactions and environmental modifiers of depression in children

J Kaufman, BZ Yang, H Douglas-Palumberi… - Biological …, 2006 - Elsevier
BACKGROUND: Child abuse and genotype interact to contribute to risk for depression in
children. This study examined gene-by-gene and gene-by-environment interactions …

Interaction of chronic stress with serotonin transporter and catechol‐O‐methyltransferase polymorphisms in predicting youth depression

CC Conway, C Hammen, PA Brennan… - Depression and …, 2010 - Wiley Online Library
Background: Investigations of gene–environment interaction (G× E) in depression have
implicated a polymorphism in the promoter region of the serotonin transporter gene (5 …

Chronic family stress interacts with 5‐HTTLPR to predict prospective depressive symptoms among youth

JL Jenness, MA, BL Hankin, Ph. D… - Depression and …, 2011 - Wiley Online Library
Background: Previous research, predominantly with adults, has shown that the serotonin
transporter gene (5‐HTTLPR) interacts with stress (G× E) to predict depressive symptoms; …