Therapeutic role of tocilizumab in SARS-CoV-2-induced cytokine storm: rationale and current evidence

C Pelaia, C Calabrese, E Garofalo, A Bruni… - International Journal of …, 2021 - mdpi.com
… rationale of tocilizumab utilization in the SARS-CoV-2-triggered cytokine storm, as well as
to … of tocilizumab’s therapeutic effects in patients with life-threatening SARS-CoV-2 infection. …

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

X Zhang, Y Zhang, W Qiao, J Zhang, Z Qi - International …, 2020 - Elsevier
… In this paper, we will elaborate the role of cytokine storm mediated by JAK-STAT pathway in
… baricitinib blocking SARS-CoV-2 entry into the target cells and controlling the cytokine storm, …

[HTML][HTML] Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges

FEM Ali, ZM Mohammedsaleh, MM Ali… - World Journal of …, 2021 - ncbi.nlm.nih.gov
… receptors and cytokine storm overwhelming, … of SARS-CoV-2 on hepatic impairment
conditions we overviewed. Besides, we focused on the recent studies that indicated cytokine storm

Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
… Nevertheless, IL-6-blocking … , as IL-6 is not solely responsible for the cytokine storm in
COVID-19 because it still remains unclear whether elevated IL-6 in viral infections, and SARS-CoV-…

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

P Laurent, C Yang, AF Rendeiro… - Science …, 2022 - science.org
… pDCs are at the eye of the storm In severe COVID-19, macrophages induce cytokine storms,
… not directly infected by SARS-CoV-2, so how this cytokine storm is induced remains unclear. …

Shelter from the cytokine storm: pitfalls and prospects in the development of SARS-CoV-2 vaccines for an elderly population

A Ciabattini, P Garagnani, F Santoro… - Seminars in …, 2020 - Springer
… risk of COVID-19-related “cytokine storm syndrome” with an overlap between the … of
SARS-CoV-2 infection. The complex and still unclear immunopathological mechanisms of SARS-CoV

[HTML][HTML] A network-based analysis reveals the mechanism underlying vitamin D in suppressing cytokine storm and virus in SARS-CoV-2 infection

F Ahmed - Frontiers in immunology, 2020 - frontiersin.org
… of pro-inflammatory cytokines through … cytokine storm in SARS-CoV-2 infection. The proposed
underlying mechanism of Vitamin D could be promising in suppressing the cytokine storm

Cytokine storm syndrome in coronavirus disease 2019: A narrative review

YM Gao, G Xu, B Wang, BC Liu - Journal of internal medicine, 2021 - Wiley Online Library
… some differences from the cytokine storms in other clinical settings… pathogenesis of cytokine
storm induced by SARS-CoV-2. … an important role in cytokine storm induced by SARS-CoV-2. …

From anti-SARS-CoV-2 immune response to the cytokine storm via molecular mimicry

D Kanduc - Antibodies, 2021 - mdpi.com
cytokine storms associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV
with the SARS-CoV-2 spike glycoprotein (gp) using public databases. It was found that the …

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options

Y Nazerian, M Ghasemi, Y Yassaghi, A Nazerian… - International …, 2022 - Elsevier
… Furthermore, cytokine storm can cause post-COVID-19 … in COVID-19-related cytokine
storm and its association with multi-… targets to control cytokine storm wishing to answer unmet …