SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

D Beckman, A Bonillas, GB Diniz, S Ott, JW Roh… - Cell reports, 2022 - cell.com
… whether SARS-CoV-2 reaches the brain and how viral neurotropism can be modulated
by aging in a non-human primate model of COVID-19. Seven days after infection, SARS-CoV-2 …

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
… of the SARS-CoV-2 spike protein and have been modified to have an extended half-life. The
antibody combination protected nonhuman primates from infection with SARS-CoV-2 when …

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

BE Jones, PL Brown-Augsburger, KS Corbett… - Science translational …, 2021 - science.org
… the severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2) spike protein
and … lower respiratory tracts of nonhuman primates from becoming infected with SARS-CoV-2. …

SARS-CoV-2 infection in nonhuman primates alters the composition and functional activity of the gut microbiota

H Sokol, V Contreras, P Maisonnasse, A Desmons… - Gut …, 2021 - Taylor & Francis
… of nonhuman primate systems – the closest to humans phylogenetically – and evaluated the
consequences of a SARS-CoV… but not, surprisingly, in nonhuman primates. Furthermore, the …

SARSCoV‐2 surveillance for a nonhuman primate breeding research facility

JAL Yee, KKA Van Rompay… - Journal of medical …, 2020 - Wiley Online Library
Non-human primates at CNPRC are at risk of SARS-CoV-2 infection from humans primarily,
but also from susceptible feral animals (such as cats 35 ). Reducing entry of people to …

[PDF][PDF] Comparison of SARS-CoV-2 infection in two non-human primate species: Rhesus and Cynomolgus macaques

KP Böszörményi, MA Stammes, ZC Fagrouch… - BioRxiv, 2020 - researchgate.net
… relatively minor discomfort to the animals. 340 In most SARS-CoV-2 studies in non-human
primates, the animals are euthanized shortly after … The animals from this study were not 342 …

Comparison of nonhuman primates identified the suitable model for COVID-19

S Lu, Y Zhao, W Yu, Y Yang, J Gao, J Wang… - Signal transduction and …, 2020 - nature.com
… More specifically, to determine the pathological responses to SARS-CoV-2 infection, we
necropsied eight animals at the early and late stages of infection according to viral load and …

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S Rauch, K Gooch, Y Hall, FJ Salguero, MJ Dennis… - Biorxiv, 2020 - biorxiv.org
… in a rhesus macaque SARS-CoV-2 challenge model. Non-human primates develop mild …
changes indicative of viral pneumonia upon infection with SARS-CoV-2 29,30 . In this study we …

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection

MS Vermillion, E Murakami, B Ma, J Pitts… - Science Translational …, 2021 - science.org
virus is cleared from most respiratory samples by 10 days after infection. The rapid SARS-CoV-2
replication in nonhuman primates… , which targets replicating virus. The studies described …

Immunodominant SARS coronavirus epitopes in humans elicited both enhancing and neutralizing effects on infection in non-human primates

Q Wang, L Zhang, K Kuwahara, L Li, Z Liu… - ACS infectious …, 2016 - ACS Publications
… ) of SARS-CoV infection in vitro and in non-human primatesSARS patients, we identified
and characterized SARS-CoV B-… prevented infection in non-human primates. In contrast, …