SARS-CoV-2 viral dynamics in non-human primates

A Gonçalves, P Maisonnasse, F Donati… - PLoS computational …, 2021 - journals.plos.org
Non-human primates infected with SARS-CoV-2 develop a mild infection resembling
asymptomatic human infection. Here we used viral dynamic modelling to characterize the …

Hydroxychloroquine use against SARS-CoV-2 infection in non-human primates

P Maisonnasse, J Guedj, V Contreras, S Behillil… - Nature, 2020 - nature.com
… We next studied infection in a model of reconstituted human airway epithelium (… the human
airway epithelium model; doses of 1 μM or 10 μM HCQ did not significantly reduce SARS-CoV

Comparison of SARS-CoV-2 infections among 3 species of non-human primates

S Lu, Y Zhao, W Yu, Y Yang, J Gao, J Wang, D Kuang… - BioRxiv, 2020 - biorxiv.org
… and gender affect SARS-CoV-2 infection in non-human primates (Figure 1). Two families of
… affect the infection of SARS-CoV-2 in these monkeys. The non-human primate model in this …

Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans

PJ Klasse, DF Nixon, JP Moore - Science advances, 2021 - science.org
coronavirus disease 2019 pandemic. The leading candidates have now been evaluated in
nonhuman primates (NHPs) and human … these vaccines in NHPs and humans. To the extent …

Exacerbated innate host response to SARS-CoV in aged non-human primates

SL Smits, A de Lang, JMA van den Brand… - PLoS …, 2010 - journals.plos.org
… For SARS-CoV-associated disease in humans, it has been hypothesized that seemingly
excessive pro-inflammatory responses, illustrated by elevated levels of inflammatory cytokines …

Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates

I Rutkai, MG Mayer, LM Hellmers, B Ning… - Nature …, 2022 - nature.com
… Our findings are consistent with those reported on autopsied brain of human subjects who
died with SARS-CoV-2 infection. Additional molecular analyses on brain from our animal …

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

YM Loo, PM McTamney, RH Arends… - Science translational …, 2022 - science.org
… of the SARS-CoV-2 spike protein and have been modified to have an extended half-life. The
antibody combination protected nonhuman primates from infection with SARS-CoV-2 when …

Overview of nonhuman primate models of SARS-CoV-2 infection

AM Trichel - Comparative Medicine, 2021 - ingentaconnect.com
… that inhibits replication of MERS-CoV and SARS-CoV in human airway epithelial cell
cultures and in SARSCoV infected mice.When tested in SARS-CoV-2 infected RM shortly after …

[PDF][PDF] SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

D Beckman, A Bonillas, GB Diniz, S Ott, JW Roh… - Cell reports, 2022 - cell.com
… However, it is still under debate whether SARS-CoV-2 directly infects … SARS-CoV-2 reaches
the brain and how viral neurotropism can be modulated by aging in a non-human primate

Immunodominant SARS coronavirus epitopes in humans elicited both enhancing and neutralizing effects on infection in non-human primates

Q Wang, L Zhang, K Kuwahara, L Li, Z Liu… - ACS infectious …, 2016 - ACS Publications
… syndrome (SARS) is caused by a coronavirus (SARS-CoV) … ) of SARS-CoV infection in vitro
and in non-human primatesSARS patients, we identified and characterized SARS-CoV B-…