Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Y Jamilloux, T Henry, A Belot, S Viel, M Fauter… - Autoimmunity …, 2020 - Elsevier
cytokine storm syndromes, such as reHLH associated with adult-onset Still’s disease [120],
or CRS secondary to CAR T cell therapies [28,121]. Several drugs are available, including …

COVID-19-associated cytokine storm syndrome and diagnostic principles: an old and new Issue

X Yongzhi - Emerging microbes & infections, 2021 - Taylor & Francis
… deterioration with the onset of fatal cytokine storm syndrome (CSS), which have increased
interest in CSS’s mechanisms, diagnosis and therapy. Although the prototypic concept of CSS …

On the alert for cytokine storm: immunopathology in COVID‐19

LA Henderson, SW Canna, GS Schulert… - Arthritis & …, 2020 - Wiley Online Library
cytokine release syndrome suggests that early intervention is … high-quality evidence of
treatment efficacy is available, … from current clinical experience in cytokine storm syndromes. …

… in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome

O Halyabar, MH Chang, ML Schoettler… - Pediatric …, 2019 - Springer
… Decisions surrounding the start of therapy in HLH/MAS patients are often the … intervention.
It is for this reason that the HLH/MAS workgroup focused its recommendations on treatment

The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
syndrome and death. The objective of this study was to provide an evidence-based review of
the associated pathways and potential treatment … material for these activities can be read in …

A “window of therapeutic opportunity” for anti-cytokine therapy in patients with coronavirus disease 2019

L De Stefano, F Bobbio-Pallavicini, A Manzo… - Frontiers in …, 2020 - frontiersin.org
cytokines which are injurious to host cells similarly to what happens in other hyperinflammatory
syndromes characterized by cytokine storms… , but interventions targeting single cytokines

Cytokines and chemokines in SARS-CoV-2 infections—therapeutic strategies targeting cytokine storm

A Pum, M Ennemoser, T Adage, AJ Kungl - Biomolecules, 2021 - mdpi.com
… Chemokines are considered powerful biomarkers and therapeutic targets in a series of
diseases like atherosclerosis, multiple sclerosis, and colitis [23,24,25,26,27,28,29]. Thus, the …

Is a “cytokine storm” relevant to COVID-19?

P Sinha, MA Matthay, CS Calfee - JAMA internal medicine, 2020 - jamanetwork.com
… the use of potent immunomodulatory therapies both in the setting … Interventions targeting
single cytokines in sepsis, … immune response or cytokine storm syndrome can lead to pulmonary …

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
cytokine storm or cytokine release syndrome (CRS), it is still unclear which molecular triggers
fuel the onset of the cytokine storm … It remains unknown if the observed cytokine storm and …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
… in COVID-19 disease severity as well as potential therapeutic … between the cytokine storm
syndrome and severity leading … Interventions such as oxygen therapy, physical activity and …