Cytokine release syndrome in severe COVID-19

JB Moore, CH June - Science, 2020 - science.org
… of a cytokine storm by T cell hyperactivation. Patients receiving such therapy and showing
a … identification of a cytokine storm is critical, and early intervention with IL-6 antagonist may …

Cannabidiol modulates cytokine storm in acute respiratory distress syndrome induced by simulated viral infection using synthetic RNA

H Khodadadi, ÉL Salles, A Jarrahi… - Cannabis and …, 2020 - liebertpub.com
… There is an urgent need for definitive therapeutic intervention. Clinical reports indicate that
the cytokine storm associated with acute respiratory distress syndrome (ARDS) is the leading …

Biomarkers of cytokine storm as red flags for severe and fatal COVID-19 cases: A living systematic review and meta-analysis

AKG Melo, KM Milby, ALMA Caparroz, ACPN Pinto… - PloS one, 2021 - journals.plos.org
… as important biomarkers of cytokine storm syndrome. Elevated levels … and of those who
require specific interventions or treatments. … but could also improve therapeutic decision making. …

The roles of neutrophils in cytokine storms

L Chan, N Karimi, S Morovati, K Alizadeh, JE Kakish… - Viruses, 2021 - mdpi.com
… the development of cytokine storm syndromes. Evidence for the … Further, a variety of potential
therapeutic strategies that … to develop efficacious therapeutic interventions for preventing …

The pathogenesis and treatment of theCytokine Storm'in COVID-19

Q Ye, B Wang, J Mao - Journal of infection, 2020 - Elsevier
cytokine storm and the options to inhibit the cytokine storm, in … mainly applied in autoimmune
diseases such as rheumatoid … These activities of ulinastatin promote the balance between …

Lessons learned to date on COVID-19 hyperinflammatory syndrome: considerations for interventions to mitigate SARS-CoV-2 viral infection and detrimental …

M Cardone, M Yano, AS Rosenberg… - Frontiers in …, 2020 - frontiersin.org
… the intervention with the drugs listed in this review, we have grouped these therapeutics
according … This cytokine storm creates an inflammatory microenvironment in the tissue, already …

… cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to counter cytokine storm

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
… the hyperinflammatory reactions in COVID-19 therapeutic interventions [150,151]. Inhibition
… with the hyperinflammatory syndrome/cytokine storm. Therefore, therapeutic approaches for …

SARS-CoV-2 causes a different cytokine response compared to other cytokine storm-causing respiratory viruses in severely ill patients

M Olbei, I Hautefort, D Modos, A Treveil… - Frontiers in …, 2021 - frontiersin.org
… help specialists identify interventions that alleviate CRS in different diseases and evaluate
treatment strategy for future cases. Recent reviews have attempted to compare diseases

Interplay between interleukin-6 signaling and the vascular endothelium in cytokine storms

S Kang, T Kishimoto - Experimental & molecular medicine, 2021 - nature.com
diseases, and we discuss the targeting IL-6 and/or IL-6R as a clinical therapeutic strategy
for cytokine storms. … without blocking the cytotoxic activities of engineered T cells directed …

In the eye of the storm: immune-mediated toxicities associated with CAR-T cell therapy

JG Borrega, P Gödel, MA Rüger, ÖA Onur… - …, 2019 - journals.lww.com
… These toxicities require urgent diagnostic and therapeutic interventionsdiseases. Both
conditions are characterized by a dysregulated immune response resulting in a cytokine storm. …