Advances in the molecular mechanisms of NLRP3 inflammasome activators and inactivators

D Liu, X Zeng, X Li, C Cui, R Hou, Z Guo… - Biochemical …, 2020 - Elsevier
… The importance of NLRP3 inflammasome in immunity and human diseases has been well …
of NLRP3 inflammasome complex and of its activation was thought to be therapeutic strategy

The NLRP3 inflammasome in the pathogenesis and treatment of Alzheimer's disease

M Golzari-Sorkheh, CE Brown… - Journal of …, 2021 - content.iospress.com
… Current therapeutic strategies targeting the NLRP3 axis consist of biologicals such as
anakinra, an IL-1β antagonist, and canakinumab, a neutralizing monoclonal antibody [76]. …

Targeting the NLRP3 inflammasome in glaucoma

S Coyle, MN Khan, M Chemaly, B Callaghan, C Doyle… - Biomolecules, 2021 - mdpi.com
… Activation of the NLRP3 inflammasome results in IL-1β … the NLRP3 inflammasome as a
therapeutic strategy. A hypothetical mechanism for the action of the NLRP3 inflammasome in …

[HTML][HTML] NLRP3 inflammasome pathways in atherosclerosis

M Baldrighi, Z Mallat, X Li - Atherosclerosis, 2017 - Elsevier
… basic mechanisms of inflammasome activation and their … NLRP3 inflammasome activation,
and discuss the current findings and therapeutic strategies that target NLRP3 inflammasome

Recent progress on the discovery of NLRP3 inhibitors and their therapeutic potential

M Su, W Wang, F Liu, H Li - Current Medicinal Chemistry, 2021 - ingentaconnect.com
… of NLRP3 inflammasome inhibitors and their therapeutic … The development of a full range
of NLRP3 inflammasome … most potent therapeutic strategies and efficiently treat NLRP3

The roles of the NLRP3 inflammasome in neurodegenerative and metabolic diseases and in relevant advanced therapeutic interventions

RH Pirzada, N Javaid, S Choi - Genes, 2020 - mdpi.com
… The NLRP3 belongs to the subfamily of NLRP which activates … This inflammasome is
involved in multiple … Therefore, therapeutic targeting to the NLRP3 inflammasome complex is a …

The NLRP3 inflammasome: a potential therapeutic target for traumatic brain injury

S Ismael, HA Ahmed, T Adris, K Parveen… - Neural regeneration …, 2021 - journals.lww.com
NLRP3 inflammasome in the pathophysiology of TBI, and current advances and challenges
in potential NLRP3-targeted therapies… effort to elucidate therapeutic strategies for attenuating …

The NLRP3 inflammasome: an emerging therapeutic target for chronic pain

R Chen, C Yin, J Fang, B Liu - Journal of neuroinflammation, 2021 - Springer
… review also summarized the successful therapeutic approaches that target against NLRP3
… the successful therapeutic approaches that target against NLRP3 inflammasome for chronic …

Therapeutic targeting of NLRP3 inflammasomes by natural products and pharmaceuticals: a novel mechanistic approach for inflammatory diseases

S Jahan, D Kumar, S Chaturvedi… - Current medicinal …, 2017 - ingentaconnect.com
NLRP3 inflammasome activity in acute and chronic inflammatory diseases. By modulating
the conformation of the NLRP3 inflammasome, selective therapeuticstherapeutic strategies

The role of NLRP3 inflammasome in Alzheimer's disease and potential therapeutic targets

T Liang, Y Zhang, S Wu, Q Chen, L Wang - Frontiers in Pharmacology, 2022 - frontiersin.org
… and downstream signaling pathways of the NLRP3 inflammasome, as well as the latest
developments regarding its potential targets and therapeutic strategies for AD treatment. …