… a threshold overlooking a new and different era,1 and has led to the evolving concept of
COVID-19 cytokine storm syndrome (… of inflammatory cytokines such as interleukin-6 (IL-6) were …

… limit of reference range in COVID-19 patients, being magnified in those with adverse clinical
progression [6]. Nonetheless, despite the onset of a “cytokine storm… cytokine storm syndrome …

… cytokine storm syndrome (CSS), which have increased interest in CSS’s mechanisms, diagnosis
and therapy. Although the prototypic concept of … cytokines, which lower the threshold for …

… of cytokine storm syndrome (CSS), have contributed to inconsistent findings of cytokine
signatures, particularly with COVID severity. Here, we measured 38 plasma cytokines and …

… a distinction between the terms “cytokine storm” and “cytokine release syndrome” (CRS). …
-like behavior due to longer time spent between cytokine-specific thresholds y 1 and y 2 (Figure …

… Syndrome led early investigators to suspect a “cytokine storm” … cytokine storm” as there
is no clear threshold of cytokine release to define the term nor would an arbitrary threshold …

… Because life-threatening CSSs may occur in nearly any context, we recommend a low
threshold for screening in-patients with fever and/or unexplained inflammatory features with serum …

… numerous patients with this disorder. Mudd et al. … cytokines must be to constitute a cytokine
storm. We would also like to include specific cytokines and thresholds in our unifying definition…

… with those who do not), supporting the concept that CSS underlies severe complications of
SARS-CoV-2 (25, 26). A delayed multisystem inflammatory syndrome (ie, MIS-C) may occur …

The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome (COVID-CSS)
emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV…