Therapeutic implications of ongoing alveolar viral replication in COVID-19

D McGonagle, MF Kearney, A O'Regan… - The Lancet …, 2022 - thelancet.com
… Furthermore, post-viral cytokine storm scenarios might occasionally occur, although this is …
in cytokine storm syndromes in patients receiving CAR T-cell therapy. Low IL-6 concentrations …

Cytokine storm and neuropathological alterations in patients with neurological manifestations of COVID-19

C Tsagkaris, M Bilal, I Aktar, Y Aboufandi… - Current Alzheimer …, 2022 - ingentaconnect.com
cytokine storm. The latter can cooccur with multiple organ failure, frequently involving the heart
and lungs, disseminated … , 101]; viral meningitis has been associated with cytokine storm, …

[PDF][PDF] A Review of Cytokine Storm in COVID-19

AS Meenakshi, M Singhai, R Goyal - Indian Journal of Medical Biochemistry, 2020 - ijmb.in
dissemination of virus, resulting in viral shedding in respiratory secretions, stools, urine,
and possibly even in sweat.It has been postulated that a preceding infection by another …

Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm

A Rabiu Abubakar, R Ahmad, AB Rowaiye, S Rahman… - Life, 2022 - mdpi.com
Cytokine storm is one of the critical complications of COVID-19 infection leading to death. …
of the cytokine storm to minimize the morbidity and mortality associated with this viral disease. …

Immunotherapeutic implications of IL-6 blockade for cytokine storm

T Tanaka, M Narazaki, T Kishimoto - Immunotherapy, 2016 - Taylor & Francis
… play a pathological role in tissue hypoxia, hypotension, disseminated intravascular … by
influenza virus infection (H1N1), loss of IL-6 results in persistence of the virus in the lung …

COVID-19, mast cells, cytokine storm, psychological stress, and neuroinflammation

D Kempuraj, GP Selvakumar, ME Ahmed… - The …, 2020 - journals.sagepub.com
… The medications for COVID-19 should target and inhibit viral replication, cytokine storm, and
hyperinflammatory responses to reduce acute lung injury, organ failure, neuroinflammation, …

The role of cytokines and chemokines in severe acute respiratory syndrome coronavirus 2 infections

RJ Hsu, WC Yu, GR Peng, CH Ye, SY Hu… - Frontiers in …, 2022 - frontiersin.org
… a cytokine storm. Neutrophils may also lead to endothelial injury, which can further promote
systemic virus dissemination (… for progressive virus replication, cytokine storm development, …

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and …

J Wang, M Jiang, X Chen… - Journal of Leucocyte …, 2020 - academic.oup.com
viral production, and a cytokine storm or cytokine release syndrome (CRS), it is still unclear
which molecular triggers fuel the onset of the cytokine storm … the observed cytokine storm and …

Immunopathogenesis of different emerging viral infections: evasion, fatal mechanism, and prevention

B Yang, KD Yang - Frontiers in Immunology, 2021 - frontiersin.org
viruses do not cause systemic virus dissemination in the blood, but cause a systemic immune
response with cytokine storm, … viruses (Table 2). Patients with fatal H5N1 infections had a …

[HTML][HTML] Cytokine storm in novel coronavirus disease (COVID-19): expert management considerations

Y Mehta, SB Dixit, KG Zirpe… - Indian journal of critical …, 2020 - ncbi.nlm.nih.gov
… be due to virus-activated “cytokine storm syndrome” or … cytokine adsorber designed to
broadly reduce cytokine storm. Though these therapies can be used in managing cytokine storm, …