Low-molecular-weight heparin in patients with advanced cancer: a phase 3 clinical trial

K Sideras, PL Schaefer, SH Okuno, JA Sloan… - Mayo Clinic …, 2006 - Elsevier
OBJECTIVE To prospectively assess whether low-molecular-weight heparin (LMWH)
provides a survival benefit in patients with advanced cancer. PATIENTS AND METHODS …

[HTML][HTML] The effect of low‐molecular‐weight heparin on cancer survival. A systematic review and meta‐analysis of randomized trials

A Lazo‐Langner, GD Goss, JN Spaans… - Journal of Thrombosis …, 2007 - Elsevier
Background: Low‐molecular‐weight heparins (LMWH) have an antitumor effect in vitro and
in experimental animal models of malignancy. Retrospective data suggest that it might …

[HTML][HTML] The effect of low molecular weight heparin on survival in cancer patients: an updated systematic review and meta‐analysis of randomized trials

D Sanford, A Naidu, N Alizadeh… - Journal of Thrombosis and …, 2014 - Elsevier
Background Tumors may exploit the coagulation system to enhance the survival and
dissemination of cancer cells. Some studies have suggested that heparin and low molecular …

The efficacy and safety of low-molecular-weight heparin use for cancer treatment: a meta-analysis

DH Che, JY Cao, LH Shang, YC Man, Y Yu - European journal of internal …, 2013 - Elsevier
BACKGROUND: Low-molecular-weight heparin (LMWH) has an anti-tumour effect in-vitro
and in animal models of malignancy; however, the evidence from clinical trials is …

Improved cancer mortality with low-molecular-weight heparin treatment: a review of the evidence

RH Cosgrove, LR Zacharski, E Racine… - … in thrombosis and …, 2002 - thieme-connect.com
Work with low-molecular-weight heparins (LMWHs) continues to provide suggestions for
survival advantages among patients with cancer diagnoses. Momentum is building in …

The effect of low molecular weight heparin on survival in patients with advanced malignancy

CPW Klerk, SM Smorenburg, HM Otten… - Journal of clinical …, 2005 - ascopubs.org
Purpose Studies in cancer patients with venous thromboembolism suggested that low
molecular weight heparin may prolong survival. In a double-blind study, we evaluated the …

Low-molecular-weight heparin and cancer

LR Zacharski, DL Ornstein… - Seminars in thrombosis …, 2000 - thieme-connect.com
Heparin is a familiar anticoagulant drug with properties that may impede tumor growth; it
modifies properties of cells that contribute to malignant dissemination such as angiogenesis …

Low molecular weight heparin and cancer survival: clinical trials and experimental mechanisms

N Zhang, W Lou, F Ji, L Qiu, BK Tsang, W Di - Journal of cancer research …, 2016 - Springer
Introduction The relationship between cancer and thrombosis is complex, as the hemostatic
system is inextricably linked to the mechanisms of cancer growth and metastasis. The …

Do heparins do more than just treat thrombosis? The influence of heparins on cancer spread

RJK Hettiarachchi, SM Smorenburg… - Thrombosis and …, 1999 - thieme-connect.com
The influence of unfractionated heparin (UFH) and other anticoagulants on the spread of
cancer has been reported since the early 1960s. 1 However, clinical studies investigating …

Low-molecular-weight heparin in cancer-associated thrombosis: treatment, secondary prevention, and survival

J Nishioka, S Goodin - Journal of Oncology Pharmacy …, 2007 - journals.sagepub.com
Objectives. Venous thromboembolism (VTE) occurs more frequently in cancer patients than
in non-cancer patients and outcomes are poor in patients with both cancer and thrombosis …