Integrin α IIb β 3 functions as the fibrinogen receptor on platelets and mediates platelet
aggregation and clot retraction. Among the events that occur during either" inside-out" or" …

ABSTRACT pp125FAK (focal adhesion kinase) a protein tyrosine kinase that may mediate
cellular responses to adhesion, is activated and tyrosine-phosphorylated when platelets …

Binding of integrins to the extracellular matrix (ECM) activates various signal transduction
pathways and regulates gene expression in many cell types. Integrin-dependent …

We have previously shown that mutation of the two tyrosines in the cytoplasmic domain of
integrin subunit β1 (Y783 and Y795) to phenylalanines markedly reduces the capability of …

The integrins have recently been implicated in signal transduction. A likely mediator of
integrin signaling is focal adhesion kinase (pp125FAK or FAK), a structurally distinct protein …

Focal adhesion kinase, pp125FAK, is a nonmyristylated cytosolic tyrosine kinase unrelated
to protein-tyrosine kinase families categorized to date. The kinase activity and tyrosine …

Tyrosine phosphorylation of multiple platelet proteins is stimulated by thrombin and other
agonists that cause platelet aggregation and secretion. The phosphorylation of a subset of …

Integrin-mediated adhesion of cells to extracellular matrix proteins triggers a variety of
intracellular signaling pathways including a cascade of tyrosine phosphorylations. In many …

The integrin family of heterodimeric cell surface receptors play critical roles in multiple
biological processes by mediating cellular adhesion to the extracellular matrix (ECM) …

Integrins bind extracellular matrix and transduce signals mediating cell adhesion, spreading,
and migration. It is unclear how these distinct responses follow from a common event …