Sir2 NAD-dependent deacetylases connect transcription, metabolism, and aging. Increasing
the dosage or activity of Sir2 extends life span in yeast, worms, and flies and promotes fat …

The Sir2 (silent information regulator 2) family of NAD‐dependent deacetylases regulates
aging and longevity across a wide variety of organisms, including yeast, worms, and flies. In …

NAD+-dependent Sir2 family deacetylases and insulin signaling pathway are both
conserved across species to regulate aging process. The interplay between these two …

Hepatic gluconeogenesis is a major contributing factor to hyperglycemia in the fasting and
postprandial states in type 2 diabetes mellitus (T2DM). Because Sirtuin 1 (SirT1) induces …

Abstract Aims/hypothesis Sirtuin 6 (SIRT6) has been implicated in ageing, DNA repair and
metabolism; however, its function in pancreatic beta cells is unclear. The aim of this study is …

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast,
flies, and worms. Mammals have seven Sir2 homologs (SIRT1–7). We show that SIRT4 is a …

Abstract Aims/hypothesis Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of
glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be …

Glucose homeostasis in mammals is mainly regulated by insulin signaling. It was previously
shown that SIRT6 mutant mice die before 4 weeks of age, displaying profound …

Despite their initial characterization as histone deacetylases controlling transcription, sirtuins
also turn out to be critical regulators of metabolism. In this issue of Cell, Haigis et al.(2006) …

Abstract Sirtuin 1 (S IRT1), the mammalian homolog of SIR2, was originally identified as a
NAD-dependent histone deacetylase, the activity of which is closely associated with lifespan …