Tip60 is a co-repressor for STAT3

H Xiao, J Chung, HY Kao, YC Yang - Journal of Biological Chemistry, 2003 - ASBMB
Tip60 (Tat-interactiveprotein, 60 kDa), a cellular protein with intrinsic histone
acetyltransferase activity, is involved in DNA damage repair and apoptosis. Recent studies …

Cellular functions of TIP60

V Sapountzi, IR Logan, CN Robson - … journal of biochemistry & cell biology, 2006 - Elsevier
TIP60 was originally identified as a cellular acetyltransferase protein that interacts with HIV-1
Tat. As a consequence, the role of TIP60 in transcriptional regulation has been investigated …

The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60

H Cui, M Guo, D Xu, ZC Ding, G Zhou, HF Ding… - Nature …, 2015 - nature.com
Abstract Tat-interactive protein 60 (Tip60) is a MYST histone acetyltransferase that catalyses
acetylation of the major DNA damage kinase Ataxia telangiectasia mutated (ATM), thereby …

Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene

D McAllister, X Merlo, J Lough - Gene, 2002 - Elsevier
Tat interactive protein-60 (TIP60) is a novel histone acetyltransferase-containing protein that
has been implicated in the regulation of transcription, DNA repair and apoptosis. In this …

Regulation of histone acetyltransferase TIP60 function by histone deacetylase 3

J Yi, X Huang, Y Yang, WG Zhu, W Gu, J Luo - Journal of Biological …, 2014 - ASBMB
The key member of the MOZ (monocyticleukaemia zinc finger protein), Ybf2/Sas3, Sas2, and
TIP60 acetyltransferases family, Tat-interactive protein, 60 kD (TIP60), tightly modulates a …

Regulation of TIP60 by ATF2 modulates ATM activation

A Bhoumik, N Singha, MJ O'Connell… - Journal of Biological …, 2008 - ASBMB
TIP60 (HTATIP) is a histone acetyltransferase (HAT) whose function is critical in regulating
ataxia-telangiectasia mutated (ATM) activation, gene expression, and chromatin acetylation …

Role of the histone acetyl transferase Tip60 in the p53 pathway

G Legube, LK Linares, S Tyteca, C Caron… - Journal of Biological …, 2004 - ASBMB
The histone acetyl transferase Tip60 (HTATIP) shares many properties with the tumor
suppressor p53 (TP53). Both proteins are involved in the cellular response to DNA damage …

Tip60 in DNA damage response and growth control: many tricks in one HAT

M Squatrito, C Gorrini, B Amati - Trends in cell biology, 2006 - cell.com
The Tip60 histone acetyltransferase is part of an evolutionarily conserved multisubunit
complex, NuA4, which is recruited by many transcription factors to their target promoters …

PARP-14 functions as a transcriptional switch for Stat6-dependent gene activation

P Mehrotra, JP Riley, R Patel, F Li, S Goenka - Journal of Biological …, 2011 - ASBMB
A subset of poly ADP-ribose polymerases (PARP) that also contain macro domains regulate
transcription. One such macro PARP, PARP-14 alters interleukin 4 (IL-4) and Stat6 …

A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities

C Boucheron, S Dumon, SCR Santos, R Moriggl… - Journal of Biological …, 1998 - ASBMB
STAT5A and STAT5B are two highly related transcription factors encoded by two distinct
genes. STAT5A and STAT5B are activated by a broad range of cytokines and growth factors …