Abstract The acetyltransferase Tip60/Kat5 acetylates both histone and non-histone proteins,
and is involved in a variety of biological processes. By acetylating p53, Tip60 controls p53 …

The acetyl-transferase Tip60 might influence tumorigenesis in multiple ways. First, Tip60 is a
co-regulator of transcription factors that either promote or suppress tumorigenesis, such as …

Acetylation is a prominent post-translational modification of nucleosomal histone N-terminal
tails, which regulates chromatin accessibility. Accordingly, histone acetyltransferases (HATs) …

The histone acetyltransferase TIP60, a frequent target of monoallelic loss in human
carcinomas, can acetylate many substrates, including histones and p53, and thus promote …

Cells are constantly exposed to genotoxic events that can damage DNA. To counter this,
cells have evolved a series of highly conserved DNA repair pathways to maintain genomic …

Acetylation is a major modification that is required for gene regulation, genome maintenance
and metabolism. A dysfunctional acetylation plays an important role in several diseases …

Chromatin reorganization plays an important role in DNA repair, apoptosis, and cell cycle
checkpoints. Among proteins involved in chromatin reorganization, TIP60 histone …

The ataxia telangiectasia mutant (ATM) protein kinase regulates the cell's response to DNA
damage through the phosphorylation of proteins involved in cell-cycle checkpoints and DNA …

Abstract Tat‐interactive protein 60 (Tip60) is a member of the MYST family, proteins of which
are related by an atypical histone acetyltransferase (HAT) domain. Although Tip60 has been …

Members of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, including the
ATM, DNA-PKcs, Atr, and Trrap proteins, function in signal transduction pathways that …