Screening of synthesized and isolated marine natural products for in vitro activity against
four parasitic protozoa has identified the ascidian metabolite 1, 14 …

Abstract We recently reported that 1, 14-diphenylacetamide derivatives of spermine exhibit
potent nM in vitro growth inhibition properties of Plasmodium falciparum. In an effort to …

Herein we describe the optimization of a phenotypic hit against Plasmodium falciparum
based on an aminoacetamide scaffold. This led to N‐(3‐chloro‐4‐fluorophenyl)‐2‐methyl‐2 …

From the phenotypic screening of the AstraZeneca corporate compound collection, N-aryl-2-
aminobenzimidazoles have emerged as novel hits against the asexual blood stage of …

3-Hydroxypropanamidines are a new promising class of highly active antiplasmodial agents.
The most active compound 22 exhibited excellent antiplasmodial in vitro activity with …

From a library of 61 compounds available from former studies 2, 5-bis-
acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti …

Bioassay-guided fractionation of an antimalarial extract derived from the fungus Ramaria
subaurantiaca afforded the known polyamine alkaloid, pistillarin. Nine pistillarin analogues …

Whole-cell high-throughput screening of the AstraZeneca compound library against the
asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino …

A new series of potent potent aryl/alkylated (bis) urea-and (bis) thiourea polyamine
analogues were synthesized and evaluated in vitro for their antiplasmodial activity. Altering …

Malaria continues to be a significant burden, particularly in Africa, which accounts for 95% of
malaria deaths worldwide. Despite advances in malaria treatments, malaria eradication is …