Over a decade ago Wright et al., proposed a putative antiplasmodial mechanism of action for
marine isonitriles (1, and 3–6) and isothiocyanate (2) that involved interference in heme …

The growing drug resistance of Plasmodia spp. to current antimalarial agents in the quinine
and artemisinin families further asserts the need for novel drug classes to combat malaria …

Antimalarial drugs such as chloroquine are believed to act by inhibiting hemozoin formation
in the food vacuole of the malaria parasite. We have developed a new assay for measuring …

Background: Malaria is responsible for social and economic burden in most lowincome
malaria-affected countries. Thus, newer antimalarials are needed to tackle morbidities and …

The 2-phenylbenzimidazole scaffold has recently been discovered to inhibit β-hematin
(synthetic hemozoin) formation by high throughput screening. Here, a library of 325,728 N-4 …

The protozoan parasite responsible for malaria affects over 500 million people each year.
Current antimalarials have experienced decreased efficacy due to the development of drug …

Abstract The Malaria Box, assembled by the Medicines for Malaria Venture, is a set of 400
structurally diverse, commercially available compounds with demonstrated activity against …

In a previous study, target based screening was carried out for inhibitors of β-hematin
(synthetic hemozoin) formation, and a series of triarylimidazoles were identified as active …

Malaria is a preventable and curable disease known to be caused by the parasitic infection
of Plasmodium spp., which is transmitted through the bites of infected female Anopheles …

The emergence of drug resistant strains of Plasmodium spp. creates a critical need for the
development of novel antimalarials. Formation of hemozoin, a crystalline heme …