Malaria community welcomes WHO vaccine approval
P Adepoju - The Lancet, 2023 - thelancet.com
Malaria experts have welcomed WHO's recommendation of using the R21/Matrix-M vaccine
to prevent malaria in children, following the advice of the WHO Strategic Advisory Group of …
to prevent malaria in children, following the advice of the WHO Strategic Advisory Group of …
Four-year efficacy of RTS, S/AS01E and its interaction with malaria exposure
Background The candidate malaria vaccine RTS, S/AS01E has entered phase 3 trials, but
data on long-term outcomes are limited. Methods For 4 years, we followed children who had …
data on long-term outcomes are limited. Methods For 4 years, we followed children who had …
Safety and immunogenicity of RTS, S/AS01 malaria vaccine in infants and children with WHO stage 1 or 2 HIV disease: a randomised, double-blind, controlled trial
Background Malaria remains a major global public health concern, especially in sub-
Saharan Africa. The RTS, S/AS01 malaria candidate vaccine was reviewed by the European …
Saharan Africa. The RTS, S/AS01 malaria candidate vaccine was reviewed by the European …
The time-course of protection of the RTS, S vaccine against malaria infections and clinical disease
Background Recent publications have reported follow-up of the RTS, S/AS01 malaria
vaccine candidate Phase III trials at 11 African sites for 32 months (or longer). This includes …
vaccine candidate Phase III trials at 11 African sites for 32 months (or longer). This includes …
Assessment of severe malaria in a multicenter, phase III, RTS, S/AS01 malaria candidate vaccine trial: case definition, standardization of data collection and patient …
Background An effective malaria vaccine, deployed in conjunction with other malaria
interventions, is likely to substantially reduce the malaria burden. Efficacy against severe …
interventions, is likely to substantially reduce the malaria burden. Efficacy against severe …
Policy uptake and implementation of the RTS, S/AS01 malaria vaccine in sub-Saharan African countries: status 2 years following the WHO recommendation
CB Osoro, E Ochodo, TK Kwambai, JA Otieno… - BMJ Global …, 2024 - gh.bmj.com
In October 2021, the WHO recommended the world's first malaria vaccine—RTS, S/AS01—
to prevent malaria in children living in areas with moderate-to-high transmission in sub …
to prevent malaria in children living in areas with moderate-to-high transmission in sub …
Could Less Be More? Accounting for Fractional-Dose Regimens and Different Number of Vaccine Doses When Measuring the Impact of the RTS,S/AS01E Malaria …
N Westercamp, L Osei-Tutu… - The Journal of …, 2024 - academic.oup.com
Abstract Background The RTS, S/AS01E (RTS, S) malaria vaccine is recommended for
children in malaria endemic areas. This phase 2b trial evaluates RTS, S fractional-and full …
children in malaria endemic areas. This phase 2b trial evaluates RTS, S fractional-and full …
Safety of the RTS, S/AS02D candidate malaria vaccine in infants living in a highly endemic area of Mozambique: a double blind randomised controlled phase I/IIb trial
JJ Aponte, P Aide, M Renom, I Mandomando, Q Bassat… - The Lancet, 2007 - thelancet.com
Background Malaria remains a leading global health problem that requires the improved
use of existing interventions and the accelerated development of new control methods. We …
use of existing interventions and the accelerated development of new control methods. We …
The advanced development pathway of the RTS, S/AS01 vaccine
L von Seidlein - Malaria Control and Elimination, 2019 - Springer
Following successful phase 1 and 2 trials, RTS, S/AS01 was evaluated in a large phase 3
trial in 7 African countries in which 8922 young children and 6537 infants were enrolled and …
trial in 7 African countries in which 8922 young children and 6537 infants were enrolled and …
The RTS, S/AS01 malaria vaccine in children 5 to 17 months of age at first vaccination
P Vandoolaeghe, L Schuerman - Expert review of vaccines, 2016 - Taylor & Francis
ABSTRACT The RTS, S/AS01 malaria vaccine received a positive scientific opinion from the
European Medicines Agency in July 2015. The World Health Organization recommended …
European Medicines Agency in July 2015. The World Health Organization recommended …