[PDF][PDF] RTS, S/AS01 malaria vaccine in African children

AV Hill - N Engl J Med, 2012 - core.ac.uk
To the Editor: In the article by the RTS, S Clinical Trials Partnership (Nov. 17 issue) 1 on the
phase 3 trial of RTS, S (ClinicalTrials. gov number, NCT00866619), an analysis of the …

The RTS, S/AS01 vaccine continues to show modest protection against malaria in African infants and children

PJ Rosenthal - BMJ Evidence-Based Medicine, 2015 - ebm.bmj.com
Methods In this phase III double-blind trial, 6537 infants (aged 6–12 weeks) and 8922
children (aged 5–17 months) were enrolled at 11 centres in seven countries, from 2009 to …

[HTML][HTML] First results of phase 3 trial of RTS, S/AS01 malaria vaccine in African children

RTS, S Clinical Trials Partnership - New England Journal of …, 2011 - Mass Medical Soc
Background An ongoing phase 3 study of the efficacy, safety, and immunogenicity of
candidate malaria vaccine RTS, S/AS01 is being conducted in seven African countries …

[HTML][HTML] A phase 3 trial of RTS, S/AS01 malaria vaccine in African infants

RTS, S Clinical Trials Partnership - New England Journal of …, 2012 - Mass Medical Soc
Background The candidate malaria vaccine RTS, S/AS01 reduced episodes of both clinical
and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing …

Efficacy and safety of the RTS, S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 …

RTS, S Clinical Trials Partnership (2014) - PLoS medicine, 2014 - journals.plos.org
Background A malaria vaccine could be an important addition to current control strategies.
We report the safety and vaccine efficacy (VE) of the RTS, S/AS01 vaccine during 18 mo …

Efficacy and safety of RTS, S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised …

S Rts - Lancet, 2015 - thelancet.com
Background The efficacy and safety of the RTS, S/AS01 candidate malaria vaccine during
18 months of follow-up have been published previously. Herein, we report the final results …

Long-term incidence of severe malaria following RTS, S/AS01 vaccination in children and infants in Africa: an open-label 3-year extension study of a phase 3 …

H Tinto, W Otieno, S Gesase, H Sorgho… - The Lancet Infectious …, 2019 - thelancet.com
Background Results from a previous phase 3 study showed efficacy of the RTS, S/AS01
vaccine against severe and clinical malaria in children (in 11 sites in Africa) during a 3–4 …

Design of a phase III multicenter trial to evaluate the efficacy of the RTS, S/AS01 malaria vaccine in children across diverse transmission settings in Africa

A Leach, J Vekemans, M Lievens, O Ofori-Anyinam… - Malaria journal, 2011 - Springer
Abstract Background GlaxoSmithKline Biologicals and the PATH Malaria Vaccine Initiative
are working in partnership to develop a malaria vaccine to protect infants and children living …

Seven-year efficacy of RTS, S/AS01 malaria vaccine among young African children

A Olotu, G Fegan, J Wambua… - … England Journal of …, 2016 - Mass Medical Soc
Background The candidate malaria vaccine RTS, S/AS01 is being evaluated in order to
inform a decision regarding its inclusion in routine vaccination schedules. Methods We …

Safety profile of the RTS, S/AS01 malaria vaccine in infants and children: additional data from a phase III randomized controlled trial in sub-Saharan Africa

Y Guerra Mendoza, E Garric, A Leach… - Human vaccines & …, 2019 - Taylor & Francis
ABSTRACT A phase III, double-blind, randomized, controlled trial (NCT00866619) in sub-
Saharan Africa showed RTS, S/AS01 vaccine efficacy against malaria. We now present in …