Screening of synthesized and isolated marine natural products for in vitro activity against
four parasitic protozoa identified the ascidian metabolites orthidine F (1), didemnidine B (2) …

Screening of synthesized and isolated marine natural products for in vitro activity against
four parasitic protozoa has identified the ascidian metabolite 1, 14 …

Covering: 2000 up to 2021 Natural products are an important resource in drug discovery,
directly or indirectly delivering numerous small molecules for potential development as …

This thesis is divided into two parts, assessing marine and synthetic compounds active firstly
against Plasmodium falciparum (Chapter 3 and 4) and secondly active against methicillin …

Novel drug leads for malaria therapy are urgently needed because of the widespread
emergence of resistance to all available drugs. Screening of the Harbor Branch enriched …

A series of pyridoacridone alkaloids, including the marine alkaloid ascididemin were tested
in vitro for antiparasitic activity against P. falciparum (K1, NF54), L. donovani, T. cruzi, T. b …

Abstract Diarylidenecyclohexanone (DAC) derivatives (Ia-i, IIa-c and IIIa-b) were
synthesized, characterized and screened for their in vitro antiplasmodial activities against …

Background Malaria remains a significant public health challenge in regions of the world
where it is endemic. An unprecedented decline in malaria incidences was recorded during …

This chapter summarizes recent developments and provides perspectives for marine natural
products as strategic prototypes in the development of a new generation of antimalarial …

Malaria, caused by Plasmodium parasites, continues to be a devastating global health
issue. Despite a decline in malaria related deaths over the last decade, overall progress has …