Norepinephrine alkaloids as antiplasmodial agents: Synthesis of syncarpamide and insight into the structure-activity relationships of its analogues as antiplasmodial …

EK Aratikatla, TR Valkute, SK Puri, K Srivastava… - European journal of …, 2017 - Elsevier
Syncarpamide 1, a norepinephrine alkaloid isolated from the leaves of Zanthoxylum
syncarpum (Rutaceae) exhibited promising antiplasmodial activities against Plasmodium …

Syncarpamide, a New Antiplasmodial (+)-Norepinephrine Derivative from Zanthoxylum syncarpum

SA Ross, GNN Sultana, CL Burandt… - Journal of Natural …, 2004 - ACS Publications
A new (+)-norepinephrine derivative, syncarpamide (1), along with a known coumarin,(+)-S-
marmesin (2), and one known alkaloid, decarine (3), have been isolated from the stem of …

Alkamides from the Leaves of Zanthoxylum syncarpum

SA Ross, MA Al-Azeib, KS Krishnaveni… - Journal of natural …, 2005 - ACS Publications
Three alkamides (1− 3) were isolated from the leaves of Zanthoxylum syncarpum. The
structures of the new compounds 1 and 2 were established by spectroscopic data and …

Antiplasmodial flavanones and a stilbene from Carpha glomerata

N Cho, AL Valenciano, Y Du, J Clement… - Bioorganic & medicinal …, 2018 - Elsevier
Bioassay-guided fractionation of an extract of Carpha glomerata (Cyperaceae) led to the
isolation of seven compounds. Compounds 1 (carphorin A), 3 (carphorin C), 4 (carphorin D) …

HPLC-profiling for antiplasmodial compounds—3-Methoxycarpachromene from Pistacia atlantica

M Adams, I Plitzko, M Kaiser, R Brun… - Phytochemistry Letters, 2009 - Elsevier
In the course of a medium throughput screen of 640 plant extracts for antimalarial activity an
ethyl acetate extract of Pistacia atlantica DC.(Anacardiaceae) was found to be active. With …

The Amaryllidaceae as a source of antiplasmodial crinane alkaloid constituents

JJ Nair, J van Staden - Fitoterapia, 2019 - Elsevier
Malaria is prevalent in tropical and subtropical regions of the globe. With over 200 million
cases reported annually, particularly in sub-Saharan Africa, it is an unnecessary burden to …

Design and synthesis of simplified speciophylline analogues and β‐carbolines as active molecules against Plasmodium falciparum

D Pierrot, V Sinou, SS Bun, D Parzy… - Drug Development …, 2019 - Wiley Online Library
A structure–activity relationship study of active molecules against chloroquine‐resistant
Plasmodium falciparum K1 strain is reported. Structurally simplified analogues of …

Transformation of lactone to lactam in sarcophine and antimalarial activity of the resulting N-substituted azasarcophines

KA El Sayed, KY Orabi, DC Dunbar, MT Hamann… - Tetrahedron, 2002 - Elsevier
Sarcophine (1) is a furanocembranoid diterpene first reported from the Red Sea soft coral
Sarcophyton glaucum with remarkable yields of up to 3% dry weight. Semisynthetic …

New antimalarial and cytotoxic 4-nerolidylcatechol derivatives

AC da Silva Pinto, LFR Silva, BC Cavalcanti… - European Journal of …, 2009 - Elsevier
4-Nerolidylcatechol (1) was isolated from cultivated Pothomorphe peltata root on a
multigram scale using straight-forward solvent extraction-column chromatography. New …

Antiplasmodial Activity of Alkaloids from Various Strychnos Species

M Frédérich, MJ Jacquier, P Thépenier… - Journal of Natural …, 2002 - ACS Publications
The in vitro antiplasmodial activities of 69 alkaloids from various Strychnos species were
evaluated against chloroquine-resistant and chloroquine-sensitive lines of Plasmodium …