A series of terpene isonitriles, isolated from marine sponges, have previously been shown to
exhibit antimalarial activities. Molecular modeling studies employing 3D-QSAR with receptor …

Our main interest is the characterization of compounds to support the development of
alternatives to currently marketed drugs that are losing effectiveness due to the development …

Over 40% of the world's population is affected by malaria; the incidence of drug-resistant
malaria parasites poses a severe threat to human health especially in un-derdeveloped …

We describe here the synthesis of a library of thirty-eight squaric derivatives and the
evaluation of activity against papain-, falcipain-2-and a chloroquine-resistant strain of P …

The role played by synthetic organic chemistry of marine metabolites as potential leads for
drug discovery of antimalarial agents is discussed. Syntheses of the most promising …

Bioassay-guided fractionation of the crude fermentation extract of Heterospora chenopodii
led to the isolation of a novel monoacylglyceryltrimethylhomoserine (1). The structure of this …

The marine environment is an amazing reservoir harbouring a treasure trove of
bioresources that continue to supply bioactive natural products with attractive …

Novel Schiff bases of N-substituted isatin, 1–13, were synthesized starting from isatin and N-
(4-amino-2-methylphenyl)-4-chlorophthalimide and their structures were confirmed by …

In an attempt to characterize additional structural classes that could serve as prototype
antimalarial agents, 28 structurally diverse marine derived metabolites were examined for in …

Due to the low structural diversity within the set of antimalarial drugs currently available in
the clinic and the increasing number of cases of resistance, there is an urgent need to find …