Activity-guided fractionation of the leaves from Campnosperma panamense Standl.(
Anacardiaceae) was undertaken as a part of a screening program to search new …

The organic extracts of the Red Sea soft coral Paralemnalia thyrsoides has led to the
identification of two neolemnane-type sesquiterpenoids: paralemnolins X and Y (1, 2). In …

The emergence of drug-resistant strains and new pathogens intensifies the need for new
antimicrobials. Additionally, bacterial biofilms, which contribute to persistent infections …

The 2-phenylbenzimidazole scaffold has recently been discovered to inhibit β-hematin
(synthetic hemozoin) formation by high throughput screening. Here, a library of 325,728 N-4 …

Marine macrophytes contain a variety of biologically active compounds, some reported to
have antiprotozoal activity in vitro. As a part of a screening program to search for new natural …

A structure–activity relationship study of active molecules against chloroquine-resistant
Plasmodium falciparum K1 strain is reported. Structurally simplified analogues of …

Malaria is one of the deadliest vectors of spreading diseases, which causes enormous
health concerns in the tropical world, especially in sub-Saharan countries. Despite …

A computational model has been developed for the rational design of bioactive
pharmacophore sites as an antibacterial, antifungal and antiviral candidates based on …

New antimalarials are desperately needed to overcome growing P. falciparum resistance to
the current drugs. Successful quinoline-based drugs target haemozoin formation causing a …

Medicinal plants have been an important source for the discovery of therapeutic agents for
infectious diseases. In order to explore their potential an appropriate selection of plant …