Virus-like particles as immunogens

R Noad, P Roy - Trends in microbiology, 2003 - cell.com
Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity
owing to incorrect folding of the target protein or poor presentation to the immune system …

Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development

N Kushnir, SJ Streatfield, V Yusibov - Vaccine, 2012 - Elsevier
Virus-like particles (VLPs) are a class of subunit vaccines that differentiate themselves from
soluble recombinant antigens by stronger protective immunogenicity associated with the …

Virus-like particles: passport to immune recognition

EVL Grgacic, DA Anderson - Methods, 2006 - Elsevier
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid
proteins from many viruses. In many cases such VLPs have structural characteristics and …

Virus‑like particles as a vaccine delivery system: Myths and facts

P Roy, R Noad - Human vaccines, 2008 - Taylor & Francis
Vaccines against viral disease have traditionally relied on attenuated virus strains or
inactivation of infectious virus. Subunit vaccines based on viral proteins expressed in …

Virus-like particles: flexible platforms for vaccine development

B Chackerian - Expert review of vaccines, 2007 - Taylor & Francis
Virus-like particles (VLPs) consist of viral structural proteins that, when overexpressed,
spontaneously self-assemble into particles that are antigenically indistinguishable from …

Virus-like particle vaccines and platforms for vaccine development

M Kheirvari, H Liu, E Tumban - Viruses, 2023 - mdpi.com
Virus-like particles (VLPs) have gained a lot of interest within the past two decades. The use
of VLP-based vaccines to protect against three infectious agents—hepatitis B virus, human …

The application of virus-like particles as vaccines and biological vehicles

D Yan, YQ Wei, HC Guo, SQ Sun - Applied microbiology and …, 2015 - Springer
Virus-like particles (VLPs) can be spontaneously self-assembled by viral structural proteins
under appropriate conditions in vitro while excluding the genetic material and potential …

Virus‐like particles as powerful vaccination strategy against human viruses

I Hadj Hassine, M Ben M'hadheb… - Reviews in Medical …, 2024 - Wiley Online Library
Nowadays, viruses are not only seen as causative agents of viral infectious diseases but
also as valuable research materials for various biomedical purposes, including recombinant …

Synthetic biology for bioengineering virus‐like particle vaccines

HK Charlton Hume, J Vidigal… - Biotechnology and …, 2019 - Wiley Online Library
Vaccination is the most effective method of disease prevention and control. Many viruses
and bacteria that once caused catastrophic pandemics (eg, smallpox, poliomyelitis …

Virus-like particles: the new frontier of vaccines for animal viral infections

E Crisci, J Bárcena, M Montoya - Veterinary immunology and …, 2012 - Elsevier
Vaccination continues to be the main approach to protect animals from infectious diseases.
Until recently, all licensed vaccines were developed using conventional technologies …